Arteriolar biomechanics in a rat polycystic ovary syndrome model - Effects of parallel vitamin D3 treatment

Levente Sára, G. Nádasy, P. Antal, M. Szekeres, A. Monori-Kiss, E. Horváth, A. Tőkés, G. Masszi, E. Monos, S. Várbíró

Research output: Contribution to journalArticle

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Abstract

To clarify the effects of dihydrotestosterone (DHT)-induced polycystic ovary syndrome (PCOS) on arteriolar biomechanics in a rat model and the possible modulatory role of vitamin D3.Methods and Results The PCOS model was induced in female Wistar rats by ten-weeks DHT treatment. Arteriolar biomechanics was tested in arterioles by pressure arteriography in control as well as DHT- and DHT with vitamin D3-treated animals in contracted and passive conditions. Increased wall stress and distensibility as well as increased vascular lumen were detected after DHT treatment. Concomitant vitamin D3 treatment lowered the mechanical load of the arterioles and restored the vascular diameter.Conclusion The hyperandrogenic state resulted in more rigid, less flexible arteriolar walls with increased vascular lumen compared with controls. DHT treatment caused eutrophic remodelling of gracilis arteriole. These prehypertensive alterations caused by chronic DHT treatment were mostly reversed by concomitant vitamin D3 administration.

Original languageEnglish
Pages (from-to)279-288
Number of pages10
JournalActa Physiologica Hungarica
Volume99
Issue number3
DOIs
Publication statusPublished - Sep 1 2012

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Dihydrotestosterone
Cholecalciferol
Polycystic Ovary Syndrome
Biomechanical Phenomena
Arterioles
Blood Vessels
Wistar Rats
Angiography
Pressure

Keywords

  • arteriolar biomechanics
  • dihydrotestosterone
  • PCOS
  • rat model
  • vitamin D

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Arteriolar biomechanics in a rat polycystic ovary syndrome model - Effects of parallel vitamin D3 treatment. / Sára, Levente; Nádasy, G.; Antal, P.; Szekeres, M.; Monori-Kiss, A.; Horváth, E.; Tőkés, A.; Masszi, G.; Monos, E.; Várbíró, S.

In: Acta Physiologica Hungarica, Vol. 99, No. 3, 01.09.2012, p. 279-288.

Research output: Contribution to journalArticle

Sára, Levente ; Nádasy, G. ; Antal, P. ; Szekeres, M. ; Monori-Kiss, A. ; Horváth, E. ; Tőkés, A. ; Masszi, G. ; Monos, E. ; Várbíró, S. / Arteriolar biomechanics in a rat polycystic ovary syndrome model - Effects of parallel vitamin D3 treatment. In: Acta Physiologica Hungarica. 2012 ; Vol. 99, No. 3. pp. 279-288.
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