Arterial stiffness, physical function, and functional limitation

The whitehall II study

Eric J. Brunner, Martin J. Shipley, Daniel R. Witte, Archana Singh-Manoux, Annie R. Britton, A. Tabák, Carmel M. McEniery, Ian B. Wilkinson, Mika Kivimaki

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Arterial stiffness has been proposed as an indicator of vascular aging. We aimed to examine this concept by analyzing associations of arterial stiffness with age, subjective and objective measures of physical functioning, and self-reported functional limitation. We measured aortic pulse wave velocity by applanation tonometry among 5392 men and women aged 55 to 78 years. Arterial stiffness was strongly associated with age (mean difference [SE] per decade: men, 1.37 m/s [0.06 m/s]; women: 1.39 m/s [0.10 m/s]). This association was robust to individual and combined adjustment for pulse pressure, mean arterial pressure, antihypertensive treatment, and chronic disease. Participants took an 8.00-ft (2.44-m) walking speed test, a spirometry lung function test, and completed health functioning and (instrumental) activities of daily living questionnaires. Associations of stiffness and blood pressure with physical function scores scaled to SD of 10 were compared. One-SD higher stiffness was associated with lower walking speed (coefficient [95% CI]:-0.96 [-1.29 to-0.64] m/s) and physical component summary score (-0.91 [-1.21 to-0.60]) and poorer lung function (-1.23 [-1.53 to-0.92] L) adjusted for age, sex, and ethnic group. Pulse pressure and mean arterial pressure were linked inversely only with lung function. Associations of stiffness with functional limitation were robust to multiple adjustment, including pulse pressure and chronic disease. In conclusion, the concept of vascular aging is reinforced by the observation that arterial stiffness is a robust correlate of physical functioning and functional limitation in early old age. The nature of the link between arterial stiffness and quality of life in older people merits attention.

Original languageEnglish
Pages (from-to)1003-1009
Number of pages7
JournalHypertension
Volume57
Issue number5
DOIs
Publication statusPublished - May 2011

Fingerprint

Vascular Stiffness
Blood Pressure
Blood Vessels
Arterial Pressure
Chronic Disease
Lung
Pulse Wave Analysis
Spirometry
Respiratory Function Tests
Manometry
Activities of Daily Living
Ethnic Groups
Antihypertensive Agents
Age Groups
Quality of Life
Health

Keywords

  • aging
  • arterial stiffness
  • epidemiology
  • functional limitation
  • physical function
  • pulse pressure

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Brunner, E. J., Shipley, M. J., Witte, D. R., Singh-Manoux, A., Britton, A. R., Tabák, A., ... Kivimaki, M. (2011). Arterial stiffness, physical function, and functional limitation: The whitehall II study. Hypertension, 57(5), 1003-1009. https://doi.org/10.1161/HYPERTENSIONAHA.110.168864

Arterial stiffness, physical function, and functional limitation : The whitehall II study. / Brunner, Eric J.; Shipley, Martin J.; Witte, Daniel R.; Singh-Manoux, Archana; Britton, Annie R.; Tabák, A.; McEniery, Carmel M.; Wilkinson, Ian B.; Kivimaki, Mika.

In: Hypertension, Vol. 57, No. 5, 05.2011, p. 1003-1009.

Research output: Contribution to journalArticle

Brunner, EJ, Shipley, MJ, Witte, DR, Singh-Manoux, A, Britton, AR, Tabák, A, McEniery, CM, Wilkinson, IB & Kivimaki, M 2011, 'Arterial stiffness, physical function, and functional limitation: The whitehall II study', Hypertension, vol. 57, no. 5, pp. 1003-1009. https://doi.org/10.1161/HYPERTENSIONAHA.110.168864
Brunner, Eric J. ; Shipley, Martin J. ; Witte, Daniel R. ; Singh-Manoux, Archana ; Britton, Annie R. ; Tabák, A. ; McEniery, Carmel M. ; Wilkinson, Ian B. ; Kivimaki, Mika. / Arterial stiffness, physical function, and functional limitation : The whitehall II study. In: Hypertension. 2011 ; Vol. 57, No. 5. pp. 1003-1009.
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