Arsenic: Association of regional concentrations in drinking water with suicide and natural causes of death in Italy

Maurizio Pompili, Monica Vichi, Enrico Dinelli, Denise Erbuto, Roger Pycha, Gianluca Serafini, Gloria Giordano, Paolo Valera, Stefano Albanese, Annamaria Lima, Benedetto De Vivo, Domenico Cicchella, Z. Ríhmer, Andrea Fiorillo, Mario Amore, Paolo Girardi, Ross J. Baldessarini

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Arsenic, as a toxin, may be associated with higher mortality rates, although its relationship to suicide is not clear. Given this uncertainty, we evaluated associations between local arsenic concentrations in tapwater and mortality in regions of Italy, to test the hypothesis that both natural-cause and suicide death rates would be higher with greater trace concentrations of arsenic. Arsenic concentrations in drinking-water samples from 145 sites were assayed by mass spectrometry, and correlated with local rates of mortality due to suicide and natural causes between 1980 and 2011, using weighted, least-squares univariate and multivariate regression modeling. Arsenic concentrations averaged 0.969 (CI: 0.543–1.396) µg/L, well below an accepted safe maximum of 10 µg/L. Arsenic levels were negatively associated with corresponding suicide rates, consistently among both men and women in all three study-decades, whereas mortality from natural causes increased with arsenic levels. Contrary to an hypothesized greater risk of suicide with higher concentrations of arsenic, we found a negative association, suggesting a possible protective effect, whereas mortality from natural causes was increased, in accord with known toxic effects of arsenic. The unexpected inverse association between arsenic and suicide requires further study.

Original languageEnglish
Pages (from-to)311-317
Number of pages7
JournalPsychiatry Research
Volume249
DOIs
Publication statusPublished - Mar 1 2017

Keywords

  • Arsenic
  • Drinking water
  • Italy
  • Mortality rates
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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    Pompili, M., Vichi, M., Dinelli, E., Erbuto, D., Pycha, R., Serafini, G., Giordano, G., Valera, P., Albanese, S., Lima, A., De Vivo, B., Cicchella, D., Ríhmer, Z., Fiorillo, A., Amore, M., Girardi, P., & Baldessarini, R. J. (2017). Arsenic: Association of regional concentrations in drinking water with suicide and natural causes of death in Italy. Psychiatry Research, 249, 311-317. https://doi.org/10.1016/j.psychres.2017.01.041