Arrhythmic death in implantable cardioverter defibrillator patients: A long-term study over a 10 year implantation period

Gabor Z. Duray, Joern Schmitt, Sergio Richter, Carsten W. Israel, Stefan H. Hohnloser

Research output: Contribution to journalArticle

30 Citations (Scopus)


Aims: Evaluation of cause-specific mortality in a large cohort of unselected implantable cardioverter defibrillator (ICD) recipients. Methods and results: Causes of death of consecutive ICD recipients implanted over a 10 year period were analysed. Overall 822 patients (age 63 ± 11 years, 80 male, EF 34 ± 14, secondary prevention 65) were followed for 43 ± 30 months during which time 225 patients died (annual mortality 7.6). Causes of death were cardiac arrhythmic in 16, cardiac non-arrhythmic in 39, non-cardiac vascular in 4, non-cardiovascular in 27, and unknown in 13. Advanced age [relative risk (RR) 1.23 per decades, 95 confidence interval (CI) 1.06-1.43], NYHA class >II (RR 2.27, 95 CI 1.51-3.41), renal failure (RR 1.57, 95 CI 1.15-2.14), use of amiodarone (RR 2.56, 95 CI 1.91-3.43), digitalis (RR 1.87, 95 CI 1.40-2.49), diuretics (RR 1.89, 95 CI 1.35-2.66) were independent predictors of all-cause mortality. Predictors for arrhythmic mortality were NYHA class >II (RR 12, 95 CI 3.69-37.5), spontaneous or inducible VT as indication for ICD therapy (RR 2.53, 95 CI 1.06-6.05), and use of amiodarone (RR 3.95, 95 CI 2.02-7.75). Conclusion: In this unselected group of ICD recipients, at least 16 of patients died from arrhythmic causes. Risk factors associated with arrhythmic mortality were a history of spontaneous or inducible VT, higher NYHA class, and amiodarone use.

Original languageEnglish
Pages (from-to)1462-1468
Number of pages7
Issue number11
Publication statusPublished - Nov 1 2009


  • Arrhythmogenic death
  • Implantable defibrillator
  • Mortality in ICD recipients
  • Sudden cardiac death

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

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