Aromatic sulfonamides containing a condensed piperidine moiety as potential oxidative stress-inducing anticancer agents

Ramóna Madácsi, Iván Kanizsai, Liliána Z. Fehér, Márió Gyuris, Béla Ózsvári, András Erdélyi, J. Wölfling, L. Puskás

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A 30-membered piperidine ring-fused aromatic sulfonamide library was synthetized, including N-arylsulfonyl 1,2,3,4-tetrahydroquinolines, 1,2,3,4-tetrahydroisoquinolines and 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indoles. The compounds induced oxidative stress and glutathione depletion in HT168 melanoma and K562 leukemia cells and in micromolar concentrations exerted cytotoxic effects. Among the tested sulfonamides, compounds 21, 22, 23, 35 and 41 exhibited 100% cytotoxic effects with low (<10 μM) EC50 values on K562 cells. The cytotoxicity of lead compound 22 was investigated in 24 different cancer cell lines, and it was found to be active against leukemia, melanoma, glioblastoma, and liver, breast and lung cancer cells, as confirmed by classical biochemical and holographic microscopic analyses.

Original languageEnglish
Pages (from-to)911-919
Number of pages9
JournalMedicinal Chemistry
Volume9
Issue number7
DOIs
Publication statusPublished - Nov 2013

Fingerprint

K562 Cells
Sulfonamides
Antineoplastic Agents
Melanoma
Leukemia
Oxidative Stress
Tetrahydroisoquinolines
Glioblastoma
Liver Neoplasms
Glutathione
Lung Neoplasms
Breast Neoplasms
Cell Line
Neoplasms
piperidine
Lead
tryptoline
1,2,3,4-tetrahydroquinoline

Keywords

  • Anticancer agent
  • Oxidative stress
  • Sulfonamide
  • Tetrahydroisoquinoline
  • Tetrahydropyridoindle
  • Tetrahydroquinoline

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Aromatic sulfonamides containing a condensed piperidine moiety as potential oxidative stress-inducing anticancer agents. / Madácsi, Ramóna; Kanizsai, Iván; Fehér, Liliána Z.; Gyuris, Márió; Ózsvári, Béla; Erdélyi, András; Wölfling, J.; Puskás, L.

In: Medicinal Chemistry, Vol. 9, No. 7, 11.2013, p. 911-919.

Research output: Contribution to journalArticle

Madácsi, Ramóna ; Kanizsai, Iván ; Fehér, Liliána Z. ; Gyuris, Márió ; Ózsvári, Béla ; Erdélyi, András ; Wölfling, J. ; Puskás, L. / Aromatic sulfonamides containing a condensed piperidine moiety as potential oxidative stress-inducing anticancer agents. In: Medicinal Chemistry. 2013 ; Vol. 9, No. 7. pp. 911-919.
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