Arginine supply for nitric oxide synthesis and arginase is mainly exogenous in elicited murine and rat macrophages

A. Hrabák, M. Idei, Ágnes Temesi

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

L-arginine, the precursor of nitric oxide(NO) is provided mainly by extracellular sources in casein-elicited murine and rat peritoneal macrophages. Free extracellular L-arginine(Arg), esters, peptides and proteins containing Arg are the best sources in accordance with the fact that proteolytic activity is high in peritoneal macrophages. The recycling of Arg from citrulline(Cit) was observed but at a low rate. This situation is different from that in endothelial cells where half of Arg is recycled from citrulline. No significant anaplerotic reaction from glutamic acid(Glu) can be demonstrated in peritoneal macrophages.

Original languageEnglish
Pages (from-to)797-805
Number of pages9
JournalLife Sciences
Volume55
Issue number10
DOIs
Publication statusPublished - 1994

Fingerprint

Arginase
Macrophages
Peritoneal Macrophages
Arginine
Rats
Citrulline
Nitric Oxide
Endothelial cells
Recycling
Caseins
Glutamic Acid
Esters
Endothelial Cells
Peptides
Proteins

Keywords

  • arginine
  • arginyl derivatives
  • macrophages

ASJC Scopus subject areas

  • Pharmacology

Cite this

Arginine supply for nitric oxide synthesis and arginase is mainly exogenous in elicited murine and rat macrophages. / Hrabák, A.; Idei, M.; Temesi, Ágnes.

In: Life Sciences, Vol. 55, No. 10, 1994, p. 797-805.

Research output: Contribution to journalArticle

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