Arginine induced growth hormone (hGH) response and paradoxical hGH secretion stimulated by TRH in diabetes mellitus

G. Winkler, László Gero, Tamás Halmos, Andrea Grósz, Gábor Gefferth, Péter Varga, G. Tamás

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Growth hormone (hGH) reserve following arginine administration and the paradoxical hGH response to thyrotropin-releasing hormone (TRH) were studied in 30 diabetics without evidence of vascular complications. The diabetics were divided into 4 groups according to the type of their disease and to the metabolic condition within the IDDM group (insulin-dependent: IDDM, in acceptable response and in poor metabolic control; non-insulin-dependent: NIDDM, and juvenile diabetics not requiring insulin at least for two years after diagnosing their disease: NIDDY). The results were compared with controls of identical age and normal weight. A paradoxical hGH response to TRH stimulation was found only in IDDM patients in poor metabolic control. In this group the hGH reserve revealed by arginine was significantly larger than in the others. It was shown that the induced hGH release was independent of the sex distribution of the groups and of the basal hGH values. Magnitude of the hGH reserve and appearance of the paradoxical hGH response were not necessarily correlated but the substantial reserve was frequently associated with a paradoxical response. It can be assumed that the unfavorable metabolic condition is of decisive importance in giving rise to these anomalies. Our observations seem to confirm the need for good metabolic control if the pathological hGH secretion in diabetics is to be prevented.

Original languageEnglish
Pages (from-to)109-117
Number of pages9
JournalActa Diabetologica Latina
Volume24
Issue number2
DOIs
Publication statusPublished - Apr 1987

Fingerprint

Thyrotropin-Releasing Hormone
Type 1 Diabetes Mellitus
Growth Hormone
Arginine
Diabetes Mellitus
Insulin
Sex Distribution
Metabolic Diseases
Type 2 Diabetes Mellitus
Blood Vessels
Weights and Measures

Keywords

  • hGH-reserve
  • IDDM
  • NIDDM
  • NIDDY
  • Paradoxical hGH-response

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Arginine induced growth hormone (hGH) response and paradoxical hGH secretion stimulated by TRH in diabetes mellitus. / Winkler, G.; Gero, László; Halmos, Tamás; Grósz, Andrea; Gefferth, Gábor; Varga, Péter; Tamás, G.

In: Acta Diabetologica Latina, Vol. 24, No. 2, 04.1987, p. 109-117.

Research output: Contribution to journalArticle

Winkler, G. ; Gero, László ; Halmos, Tamás ; Grósz, Andrea ; Gefferth, Gábor ; Varga, Péter ; Tamás, G. / Arginine induced growth hormone (hGH) response and paradoxical hGH secretion stimulated by TRH in diabetes mellitus. In: Acta Diabetologica Latina. 1987 ; Vol. 24, No. 2. pp. 109-117.
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