Are there systemic changes in the arterial biomechanics of intracranial aneurysm patients?

Mária Tóth, György L. Nádasy, István Nyáry, Tibor Kerényi, Emil Monos

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Current theories on the development of intracranial aneurysm suggest that there is a general weakness of vascular connective tissue. Potential systemic alterations in arterial wall biomechanics were tested in the present study. A three-dimensional in vitro stress-strain analysis was made in the 0- 200-0 mmHg pressure range on cylindrical segments excised from the anterior cerebral artery, the radial artery and from the arteria dorsalis pedis of aneurysm patients and of control cadavers. In the anterior cerebral artery from aneurysm patients (intracranial artery segments directly not affected by the aneurysm or by the subarachnoid bleeding), we found the wall thickness to be larger (0.148±0.019 versus 0.091±0.004 mm), the radius/wall thickness ratio smaller (9.7±1.4 versus 14.1±1.2), and the tangential wall stress lower [(0.122±0.019)x106 versus (0.181±0.016)x106 N/m2 at 100 mmHg] than in control subjects. Reduced radius was found in the extremity arteries studied. Elastic parameters, as incremental distensibility and elastic modulus, were remarkable similar. Our study demonstrates changes in the geometry of walls of arteries not directly affected by aneurysm formation, and it thus confirms systemic vascular pathology in this disease. At the same time, these data show that the molecular and morphological defects of arterial connective tissue formation generally thought to induce intracranial aneurysms will probably not affect the components responsible for the passive elastic properties of the vascular wall.

Original languageEnglish
Pages (from-to)573-578
Number of pages6
JournalPflugers Archiv European Journal of Physiology
Volume439
Issue number5
DOIs
Publication statusPublished - Mar 21 2000

Keywords

  • Arterial elasticity
  • Cerebral aneurysm Vascular biomechanical properties

ASJC Scopus subject areas

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

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