Are the strokes in moyamoya syndrome associated with Down syndrome due to protein C deficiency?

A. Gururaj, D. Hardy, L. I. Al-Gazali, L. Sztriha, A. Roos, M. Nork

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Moyamoya syndrome has occasionally been seen in association with Down syndrome. We report a child with moyamoya syndrome and Down syndrome who was admitted with repeated episodes of strokes; his magnetic resonance imaging and magnetic resonance angiography findings confirmed the presence of occlusive cerebrovascular disease with basal collateral vessels. His protein C levels were significantly decreased during the stroke. Complete clinical recovery was seen during follow-up. This raises the possibility of a link between protein C deficiency and Down syndrome with moyamoya syndrome.

Original languageEnglish
Pages (from-to)719-722
Number of pages4
JournalBrain and Development
Volume24
Issue number7
DOIs
Publication statusPublished - Oct 2002

Fingerprint

Protein C Deficiency
Moyamoya Disease
Down Syndrome
Stroke
Cerebrovascular Disorders
Magnetic Resonance Angiography
Protein C
Magnetic Resonance Imaging

Keywords

  • Down syndrome
  • Magnetic resonance angiography
  • Moyamoya disease
  • Moyamoya syndrome
  • Protein C

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

Cite this

Are the strokes in moyamoya syndrome associated with Down syndrome due to protein C deficiency? / Gururaj, A.; Hardy, D.; Al-Gazali, L. I.; Sztriha, L.; Roos, A.; Nork, M.

In: Brain and Development, Vol. 24, No. 7, 10.2002, p. 719-722.

Research output: Contribution to journalArticle

Gururaj, A. ; Hardy, D. ; Al-Gazali, L. I. ; Sztriha, L. ; Roos, A. ; Nork, M. / Are the strokes in moyamoya syndrome associated with Down syndrome due to protein C deficiency?. In: Brain and Development. 2002 ; Vol. 24, No. 7. pp. 719-722.
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