Are the MDS-UPDRS–Based Composite Scores Clinically Applicable?

Attila Makkos, Márton Kovács, Zsuzsanna Aschermann, Márk Harmat, József Janszky, Kázmér Karádi, Norbert Kovács

Research output: Contribution to journalArticle

5 Citations (Scopus)


Background: The International Parkinson and Movement Disorder Society–sponsored UPDRS (MDS-UPDRS) is a powerful clinical outcome measure. Objectives: To evaluate the feasibility of various MDS-UPDRS-based composite scores and determine their minimal clinically important difference threshold values. Methods: Overall, 1,113 paired investigations of 452 patients were reviewed implementing three different techniques simultaneously. Results: Based on the ordinal regression modeling, the MDS-UPDRS II+III, MDS-UPDRS I+II+III, and the total score of MDS-UPDRS are clinically applicable outcome measures. Any improvement greater than 4.9 points or any worsening more than 4.2 points on MDS-UPDRS II+III represent a minimal, yet clinically meaningful, change. In reference to MDS-UPDRS I+II+III, the smallest changes considered clinically relevant were 6.7 and 5.2 points for improvement and deterioration, respectively. The thresholds for the total score of MDS-UPDRS were 7.1 points for improvement and 6.3 points for worsening. Conclusions: Our findings support the application of various MDS-UPDRS–based composite scores.

Original languageEnglish
Pages (from-to)835-839
Number of pages5
JournalMovement Disorders
Issue number5
Publication statusPublished - May 2018


  • minimal but clinically relevant differences
  • minimal clinically important changes
  • patient-reported outcomes
  • receiver operating characteristic curve

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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