Background: The International Parkinson and Movement Disorder Society–sponsored UPDRS (MDS-UPDRS) is a powerful clinical outcome measure. Objectives: To evaluate the feasibility of various MDS-UPDRS-based composite scores and determine their minimal clinically important difference threshold values. Methods: Overall, 1,113 paired investigations of 452 patients were reviewed implementing three different techniques simultaneously. Results: Based on the ordinal regression modeling, the MDS-UPDRS II+III, MDS-UPDRS I+II+III, and the total score of MDS-UPDRS are clinically applicable outcome measures. Any improvement greater than 4.9 points or any worsening more than 4.2 points on MDS-UPDRS II+III represent a minimal, yet clinically meaningful, change. In reference to MDS-UPDRS I+II+III, the smallest changes considered clinically relevant were 6.7 and 5.2 points for improvement and deterioration, respectively. The thresholds for the total score of MDS-UPDRS were 7.1 points for improvement and 6.3 points for worsening. Conclusions: Our findings support the application of various MDS-UPDRS–based composite scores.
- minimal but clinically relevant differences
- minimal clinically important changes
- patient-reported outcomes
- receiver operating characteristic curve
ASJC Scopus subject areas
- Clinical Neurology