Are spatial positions of dendritic and axonal branches correlated or independent?

Armen Stepanyants, G. Tamás, Dmitri B. Chklovskii

Research output: Contribution to journalArticle

Abstract

Because direct investigation of synaptic connectivity is difficult, neurobiologists often resort to indirect methods. One method is to infer connectivity from the densities of axonal and dendritic arbors, and the arbor overlap volume. This method is valid only under the assumption that spatial positions of dendritic and axonal branches are uncorrelated on a micrometer lengthscale. We test this assumption by using 3D reconstructions of neuronal pairs from the rat neocortex. We find that the positions of GABAergic interneuron axons are correlated with their targets, while the positions of pyramidal neuron axons are independent of their targets.

Original languageEnglish
Pages (from-to)477-485
Number of pages9
JournalNeurocomputing
Volume58-60
DOIs
Publication statusPublished - Jun 2004

Fingerprint

Axons
Neurons
Rats
Pyramidal Cells
Neocortex
Interneurons

Keywords

  • Connectivity
  • Cortex
  • Excitatory
  • Inhibitory

ASJC Scopus subject areas

  • Artificial Intelligence
  • Cellular and Molecular Neuroscience

Cite this

Are spatial positions of dendritic and axonal branches correlated or independent? / Stepanyants, Armen; Tamás, G.; Chklovskii, Dmitri B.

In: Neurocomputing, Vol. 58-60, 06.2004, p. 477-485.

Research output: Contribution to journalArticle

Stepanyants, Armen ; Tamás, G. ; Chklovskii, Dmitri B. / Are spatial positions of dendritic and axonal branches correlated or independent?. In: Neurocomputing. 2004 ; Vol. 58-60. pp. 477-485.
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