Are prostaglandins involved in the regulation of coronary blood flow? A review of the evidence

J. R. Parratt, R. J. Marshall

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Prostaglandins (PG's) fulfil most of the criteria required for the metabolic 'coupler' linking increases in myocardial activity with increases in coronary blood flow. They are synthesized by the heart and coronary vessels, profoundly modify coronary blood flow in low concentrations and are released under conditions of hypoxia and myocardial ischaemia. Studies with inhibitors of PG-synthetase however provide no firm evidence that PG's are involved in the physiological regulation of myocardial blood flow. These studies are reviewed.

Original languageEnglish
Pages (from-to)747-754
Number of pages8
JournalActa biologica et medica Germanica
Volume37
Issue number5-6
Publication statusPublished - Dec 1 1978

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Are prostaglandins involved in the regulation of coronary blood flow? A review of the evidence'. Together they form a unique fingerprint.

  • Cite this