Are granulocytes the main effector cells of natural cytotoxicity in chickens?

Y. Mándi, G. Seprenyi, R. Pusztai, I. Beladi

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Abstract

Purified peripheral blood granulocytes from chicken were tested for cytotoxic activity against two types of virus-transformed chicken cell line, LSCC-H32 and LSCC-RP9. Strong cytotoxicity could be demonstrated, as measured in a 4-hr 51Cr-release assay, especially against the fibroblastoid LSCC-H32 cells. The degree of cytotoxicity was dependent on the E:T ratio. Normal CEF cells were completely resistant to the cytotoxicity. No cytotoxicity of human granulocytes could be observed against a variety of adherent and non-adherent target cells, as measured by the same microcytotoxicity technique. The priority of granulocytes in the natural cytotoxicity in the avian system is, therefore, suggested.

Original languageEnglish
Pages (from-to)284-292
Number of pages9
JournalImmunobiology
Volume170
Issue number4
Publication statusPublished - 1985

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Granulocytes
Chickens
Transformed Cell Line
Viruses

ASJC Scopus subject areas

  • Immunology

Cite this

Mándi, Y., Seprenyi, G., Pusztai, R., & Beladi, I. (1985). Are granulocytes the main effector cells of natural cytotoxicity in chickens? Immunobiology, 170(4), 284-292.

Are granulocytes the main effector cells of natural cytotoxicity in chickens? / Mándi, Y.; Seprenyi, G.; Pusztai, R.; Beladi, I.

In: Immunobiology, Vol. 170, No. 4, 1985, p. 284-292.

Research output: Contribution to journalArticle

Mándi, Y, Seprenyi, G, Pusztai, R & Beladi, I 1985, 'Are granulocytes the main effector cells of natural cytotoxicity in chickens?', Immunobiology, vol. 170, no. 4, pp. 284-292.
Mándi, Y. ; Seprenyi, G. ; Pusztai, R. ; Beladi, I. / Are granulocytes the main effector cells of natural cytotoxicity in chickens?. In: Immunobiology. 1985 ; Vol. 170, No. 4. pp. 284-292.
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