Are α-adrenergic antagonists potent tocolytics? In vivo experiments on postpartum rats

Research output: Contribution to journalArticle

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Abstract

The aim of this study was to investigate the effects of α-adrenergic antagonists on the motor activity of the postpartum uterus of the rat in vivo. Intrauterine pressure was assessed by means of a Millar catheter fitted with a latex microballoon. Some of the tested compounds (urapidil, yohimbine, phentolamine, benoxathian and prazosin) decreased the uterine activity to a significant extent (57.4-67.4%). However, none of the investigated α-receptor blockers exerted the same effect as P-adrenergic agonists. Our results suggest that α-adrenergic antagonists could possibly be used as an alternative to β-adrenergic agonists in clinical tocolysis after an appropriate clinical evaluation.

Original languageEnglish
JournalLife Sciences
Volume61
Issue number11
DOIs
Publication statusPublished - Aug 8 1997

Fingerprint

Tocolytic Agents
Adrenergic Agonists
Adrenergic Antagonists
Postpartum Period
Rats
Tocolysis
Yohimbine
Catheters
Prazosin
Phentolamine
Latex
Uterus
Motor Activity
Experiments
Pressure
urapidil
benoxathian

Keywords

  • α-adrenergic antagonists
  • Spontaneous uterine activity
  • Tocolysis

ASJC Scopus subject areas

  • Pharmacology

Cite this

Are α-adrenergic antagonists potent tocolytics? In vivo experiments on postpartum rats. / Zupkó, I.; Gáspár, R.; Kovács, L.; Falkay, G.

In: Life Sciences, Vol. 61, No. 11, 08.08.1997.

Research output: Contribution to journalArticle

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