The aim of this study was to investigate the effects of α-adrenergic antagonists on the motor activity of the postpartum uterus of the rat in vivo. Intrauterine pressure was assessed by means of a Millar catheter fitted with a latex microballoon. Some of the tested compounds (urapidil, yohimbine, phentolamine, benoxathian and prazosin) decreased the uterine activity to a significant extent (57.4-67.4%). However, none of the investigated α-receptor blockers exerted the same effect as P-adrenergic agonists. Our results suggest that α-adrenergic antagonists could possibly be used as an alternative to β-adrenergic agonists in clinical tocolysis after an appropriate clinical evaluation.
- Spontaneous uterine activity
- α-adrenergic antagonists
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- Pharmacology, Toxicology and Pharmaceutics(all)