Are α-adrenergic antagonists potent tocolytics? In vivo experiments on postpartum rats

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Abstract

The aim of this study was to investigate the effects of α-adrenergic antagonists on the motor activity of the postpartum uterus of the rat in vivo. Intrauterine pressure was assessed by means of a Millar catheter fitted with a latex microballoon. Some of the tested compounds (urapidil, yohimbine, phentolamine, benoxathian and prazosin) decreased the uterine activity to a significant extent (57.4-67.4%). However, none of the investigated α-receptor blockers exerted the same effect as P-adrenergic agonists. Our results suggest that α-adrenergic antagonists could possibly be used as an alternative to β-adrenergic agonists in clinical tocolysis after an appropriate clinical evaluation.

Original languageEnglish
Pages (from-to)PL159-PL163
JournalLife Sciences
Volume61
Issue number11
DOIs
Publication statusPublished - Aug 8 1997

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Keywords

  • Spontaneous uterine activity
  • Tocolysis
  • α-adrenergic antagonists

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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