Arachidonic acid supply and metabolism in human infants born at full term

Berthold Koletzko, T. Decsi, Hans Demmelmair

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Infants need arachidonic acid (AA; C20:4n-6) for eicosanoid synthesis and deposition in growing tissues, including brain. Human milk supplies performed AA in amounts considered to meet accretion in membrane-rich tissues, but vegetable oil-based infant formulas do not contain AA. We studied two groups of ten healthy infants, each fed human milk or formula, and analyzed plasma lipid composition. Percentage contributions of AA to plasma phospholipids were stable over two months after birth in breast-fed infants, but infants fed formula developed significantly (P13C-enrichment than European human milk or formula. Analysis of13C-enrichment in plasma fatty acids over four days allowed us to estimate infantile AA synthesis. We found an increased13C-value in plasma AA of all infants, which indicates that term neonates can synthesize AA. However, with a simplified isotope balance equation, we estimate that endogenous synthesis contributed only about 23% of total plasma arachidonic acid by day four. We conclude that full-term infants fed formula may require a dietary supply of some preformed AA if the biochemical status of breast-fed infants is to be achieved.

Original languageEnglish
Pages (from-to)79-83
Number of pages5
JournalLipids
Volume31
Issue number1
DOIs
Publication statusPublished - Jan 1996

Fingerprint

infant formulas
breast milk
arachidonic acid
Arachidonic Acid
Metabolism
Infant Formula
Plasmas
Human Milk
breasts
metabolism
synthesis
eicosanoids
infants
lipid composition
vegetable oil
Breast
blood lipids
isotopes
Tissue
phospholipids

ASJC Scopus subject areas

  • Organic Chemistry
  • Cell Biology
  • Biochemistry
  • Medicine (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Food Science

Cite this

Arachidonic acid supply and metabolism in human infants born at full term. / Koletzko, Berthold; Decsi, T.; Demmelmair, Hans.

In: Lipids, Vol. 31, No. 1, 01.1996, p. 79-83.

Research output: Contribution to journalArticle

Koletzko, Berthold ; Decsi, T. ; Demmelmair, Hans. / Arachidonic acid supply and metabolism in human infants born at full term. In: Lipids. 1996 ; Vol. 31, No. 1. pp. 79-83.
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