Arachidonic acid metabolism in reproductive tissues of pregnant guinea pig under in vivo circumstances

I. Mucha, B. Tanács, S. Bagdány

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2 Citations (Scopus)

Abstract

Uptake and metabolism of tritium labelled arachidonic acid have been studied under in vivo circumstances in placenta, uterus and fetal membranes of pregnant guinea pigs on days 40 and 60 of pregnancy. Distribution of radioactivity within the lipid fractions of the selected tissues showed a characteristic pattern depending on the gestational ages. Composition of labelled lipids was determined by radio thin layer chromatography and quantitated with liquid scintillation measurements. The main site of arachidonic acid incorporation was the 2-position of phosphatidylcholine. Near term, a considerable PGF-synthesis from exogenously administered 3-H-arachidonic acid could be demonstrated for the first time "in vivo".

Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalProstaglandins, Leukotrienes and Medicine
Volume12
Issue number2
DOIs
Publication statusPublished - Oct 1983

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ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology

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