Aptasensors for viral diagnostics

Corné H. van den Kieboom, Samantha L. van der Beek, Tamás Mészáros, Róbert E. Gyurcsányi, Gerben Ferwerda, Marien I. de Jonge

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Novel viral diagnostic tools need to be affordable, fast, accurate and easy to use with sensitivity and specificity equivalent or superior to current standards. At present, viral diagnostics are based on direct detection of viral components or indirect detection by measuring antibodies generated in response to viral infection. While sensitivity of detection and quantification are still important challenges, we expect major advances from new assay formats and synthetic binding molecules, such as aptamers. Compared to traditional antibody-based detection, aptamers could provide faster adaptation to continuously evolving virus strains and higher discriminating capacity between specific virus serotypes. Aptamers are very stable and easily modifiable, so are ideal molecules for detection and chemical sensing applications. Here, we review the use of aptasensors for detection of viral pathogens and consider the feasibility of aptasensors to become standard devices for point-of-care diagnostics of viruses.

Original languageEnglish
Pages (from-to)58-67
Number of pages10
JournalTrAC - Trends in Analytical Chemistry
Volume74
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Antibody
  • Aptamer
  • Assay
  • Detection
  • Diagnostics
  • Pathogen
  • Point of care
  • Sensor
  • Serotype
  • Virus

ASJC Scopus subject areas

  • Analytical Chemistry
  • Spectroscopy

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  • Cite this

    van den Kieboom, C. H., van der Beek, S. L., Mészáros, T., Gyurcsányi, R. E., Ferwerda, G., & de Jonge, M. I. (2015). Aptasensors for viral diagnostics. TrAC - Trends in Analytical Chemistry, 74, 58-67. https://doi.org/10.1016/j.trac.2015.05.012