Aprotinin: Pharmacological benefits and safety concerns

Andrea Székely, Daniel J. Lex, B. Merkely

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

In cardiac surgery, perioperative blood transfusion carries considerable risk of complications and increases resource utilization. Antifibrinolytics, particularly aprotinin, have been used effectively to reduce bleeding and transfusion needs. In 2008, the manufacturer withdrew aprotinin from the market due to the discontinued “Blood conservation using antifibrinolytics in a Randomized Trial” (Brat) study, which showed an increased mortality associated with the use of aprotinin.

Original languageEnglish
Title of host publicationReducing Mortality in the Perioperative Period
PublisherSpringer International Publishing
Pages125-130
Number of pages6
ISBN (Print)9783319021867, 9783319021850
DOIs
Publication statusPublished - Jan 1 2014

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Székely, A., Lex, D. J., & Merkely, B. (2014). Aprotinin: Pharmacological benefits and safety concerns. In Reducing Mortality in the Perioperative Period (pp. 125-130). Springer International Publishing. https://doi.org/10.1007/978-3-319-02186-7_16