Dinamikus lézer fényszórás-fotometria alkalmazási lehetõsége a polietilénglikol kúpalapanyagok vizsgálatára

Translated title of the contribution: Application possibilities of dynamic laser light scattering photometry for the examination of poly(ethyleneglycol) suppository

I. Bácskay, S. Kéki, Gy Deák, M. Zguga, G. Mezey

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Status epilepticus is one of the most common neurologic emergencies in children, adolescents, and young adults. The advantage of diazepam suppository in medicinal therapy appears mainly in treatment of childhood epilepsy. A hydrophilic suppository base was investigated in solution by dynamic light scattering and results were compared to those of the membrane diffusion experiments measuring diazepam solubilization. According to the dynamic laser light scattering photometric measurements, the good solubilization effect of the macrogol mixture (5% Polysorbatum 20, 10% Macrogolum 400, 85% Macrogolum 1540) is explained by the formation of small, tight micellas. As the Polysorbatum 20 tenside resulted in the significant decrease (p < 0.05) of the formation of great micellas, its use led to the formation of small, tight, almost monodisperse micellas of 40-50 nm in the aqueous solution of the macrogol mixture.

Translated title of the contributionApplication possibilities of dynamic laser light scattering photometry for the examination of poly(ethyleneglycol) suppository
Original languageHungarian
Pages (from-to)153-156
Number of pages4
JournalActa pharmaceutica Hungarica
Volume71
Issue number2
Publication statusPublished - Oct 25 2001

ASJC Scopus subject areas

  • Pharmaceutical Science

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