Application of the fundamental parameter method to the in vivo x-ray fluorescence analysis of Pt

I. Szalóki, D. G. Lewis, C. A. Bennett, A. Kilic

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The application of the fundamental parameter method (FPM) to the in vivo x-ray fluorescence (XRF) analysis of Pt has been investigated. The FPM is conventionally used to carry out elemental analysis of samples in vitro without the need to use standard samples of accurately known composition for system calibration. The present work has involved the use of the FPM to calculate the concentration of Pt solutions in phantoms, with concentrations ranging from 25-1000 ppm. The phantoms simulate the measurement of Pt-based chemotherapy drugs in head and neck tumours. The radiation sources were a 150 kV tungsten-anode x-ray tube and the isotope 99mTc. The minimum detection limit measured for Pt was in the range 8-30 ppm (depending on radiation source and geometry), using a narrow (5 mm) diameter beam. Dose rates in the phantom were 0.1-5 mGy h-1. Average differences between nominal and calculated values of Pt concentration were

Original languageEnglish
Pages (from-to)1245-1255
Number of pages11
JournalPhysics in Medicine and Biology
Volume44
Issue number5
DOIs
Publication statusPublished - May 1999

Fingerprint

x ray fluorescence
Fluorescence
X-Rays
radiation sources
Radiation
X rays
Chemotherapy
Chemical analysis
Isotopes
Tungsten
Tumors
x ray tubes
Anodes
Calibration
chemotherapy
Geometry
Limit of Detection
Electrodes
tungsten
drugs

ASJC Scopus subject areas

  • Biomedical Engineering
  • Physics and Astronomy (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Application of the fundamental parameter method to the in vivo x-ray fluorescence analysis of Pt. / Szalóki, I.; Lewis, D. G.; Bennett, C. A.; Kilic, A.

In: Physics in Medicine and Biology, Vol. 44, No. 5, 05.1999, p. 1245-1255.

Research output: Contribution to journalArticle

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