Application of sucrose fatty acid esters in transdermal therapeutic systems

G. Csóka, S. Marton, R. Zelkó, N. Otomo, I. Antal

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Transdermal therapeutic systems (TTSs) were studied applying different sucrose fatty acid esters (SEs) as drug delivery agents. Matrix and membrane controlled TTSs were prepared and compared. Membrane was made from a methacrylic polymer (Eudragit® NE) of pH independent permeability which can achieve diffusion controlled drug liberation. Model drug was a water soluble β-blocker, metoprolol, which has short biological half-life, so applying it in a TTS, the duration of its action could be prolonged. Sucrose fatty acid esters of different fatty acid chain lengths and consequently different hydrophilic-lipophilic balance (HLB) values were studied considering their effect on the metoprolol release from TTSs. Different mathematical models were applied for the evaluation of the release process. The results of the in vitro studies indicated that SEs of shorter fatty acid chain length and higher HLB value increased the amount of released drug about 10 times. SEs could be promising agents in transdermal therapeutic systems to control the drug release and cutaneous absorption.

Original languageEnglish
Pages (from-to)233-237
Number of pages5
JournalEuropean Journal of Pharmaceutics and Biopharmaceutics
Volume65
Issue number2
DOIs
Publication statusPublished - Feb 2007

Fingerprint

Sucrose
Esters
Fatty Acids
Metoprolol
Pharmaceutical Preparations
Skin Absorption
Therapeutics
Membranes
Volatile Fatty Acids
Half-Life
Permeability
Polymers
Theoretical Models
Water
Drug Liberation

Keywords

  • Drug release
  • Mathematical models
  • Metoprolol
  • Sucrose fatty acid esters
  • Transdermal delivery

ASJC Scopus subject areas

  • Biotechnology
  • Pharmaceutical Science

Cite this

Application of sucrose fatty acid esters in transdermal therapeutic systems. / Csóka, G.; Marton, S.; Zelkó, R.; Otomo, N.; Antal, I.

In: European Journal of Pharmaceutics and Biopharmaceutics, Vol. 65, No. 2, 02.2007, p. 233-237.

Research output: Contribution to journalArticle

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