Application of squaric acid esters in aminodeoxy sugar chemistry

Ferenc Sztaricskai, Erzsébet Roth, Maria Andrei, István F. Pelyvás, Pál Herczegh

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The reaction of dimethyl squarate with aminodeoxy sugars, aminodeoxy alditols, amino aldonic acids, and glycosyl amines under neutral conditions furnished the squaric amide esters, which were converted in more alkaline media (pH ≈8) into the asymmetric squaric diamides. The unprotected squaric acid amide esters are suitable for constructing a specific anchor (spacer, linker) function that favorably influences the watersolubility of the resulting drugs and glycoconjugates.

Original languageEnglish
Pages (from-to)1012-1013
Number of pages2
JournalChemistry Letters
Issue number8
Publication statusPublished - Aug 5 2007


ASJC Scopus subject areas

  • Chemistry(all)

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