Application of small molecule microarrays in comparative chemical proteomics

Eszter Molnár, Lászaló Hackler, Tamás Jankovics, Lászaló Ürge, Ferenc Darvas, Liliána Z. Fehér, Zsolt Lorincz, György Dormán, László G. Puskás

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The simultaneous identification of disease-specific protein targets and their small molecule-binding partners, suitable as drug candidates, could radically reduce the timeline and costs of drug discovery and development. Comparative chemical proteomics provides a novel approach to achieve this goal through rapid detection of overexpressed proteins in diseased samples by the application of small molecule microarrays. The interacting small molecules enable direct affinity-based isolation and identification of the proteins. In the present paper we report comparative chemical proteomics studies on melanocytes and melanoma cell-lines, which led to the identification of three overexpressed proteins together with their small molecule-binding partner.

Original languageEnglish
Pages (from-to)1020-1026
Number of pages7
JournalQSAR and Combinatorial Science
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 1 2006

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Keywords

  • Chemogenomics
  • Hit identification
  • Proteomics
  • Small molecule microarray

ASJC Scopus subject areas

  • Drug Discovery
  • Computer Science Applications
  • Organic Chemistry

Cite this

Molnár, E., Hackler, L., Jankovics, T., Ürge, L., Darvas, F., Fehér, L. Z., Lorincz, Z., Dormán, G., & Puskás, L. G. (2006). Application of small molecule microarrays in comparative chemical proteomics. QSAR and Combinatorial Science, 25(11), 1020-1026. https://doi.org/10.1002/qsar.200640080