Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine

M. A. Kiselev, E. V. Zemlyanaya, O. M. Ipatova, A. Yu Gruzinov, E. V. Ermakova, A. V. Zabelin, E. I. Zhabitskaya, O. S. Druzhilovskaya, V. Aksenov

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Phospholipid transport nanosystem (PTNS) for drug delivery is based on soybean phosphatidylcholine. The morphology of PTNS is investigated by means of small-angle X-ray scattering. The obtained results allow one to answer the key question from the viewpoint of organization of drug incorporation whether the PTNS nanoparticles have a structure of micelles or vesicles. It is demonstrated that PTNS is a vesicular system with an average vesicle radius of 160 ± 2 Å.

Original languageEnglish
Pages (from-to)288-291
Number of pages4
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume114
DOIs
Publication statusPublished - Oct 1 2015

Fingerprint

Nanosystems
X ray scattering
Phosphatidylcholines
Soybeans
Phospholipids
X-Rays
Pharmaceutical Preparations
Micelles
Drug delivery
Nanoparticles

Keywords

  • Drug carriers
  • Synchrotron
  • Vesicles
  • X-ray scattering

ASJC Scopus subject areas

  • Analytical Chemistry
  • Drug Discovery
  • Pharmaceutical Science
  • Spectroscopy
  • Clinical Biochemistry

Cite this

Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine. / Kiselev, M. A.; Zemlyanaya, E. V.; Ipatova, O. M.; Gruzinov, A. Yu; Ermakova, E. V.; Zabelin, A. V.; Zhabitskaya, E. I.; Druzhilovskaya, O. S.; Aksenov, V.

In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 114, 01.10.2015, p. 288-291.

Research output: Contribution to journalArticle

Kiselev, M. A. ; Zemlyanaya, E. V. ; Ipatova, O. M. ; Gruzinov, A. Yu ; Ermakova, E. V. ; Zabelin, A. V. ; Zhabitskaya, E. I. ; Druzhilovskaya, O. S. ; Aksenov, V. / Application of small-angle X-ray scattering to the characterization and quantification of the drug transport nanosystem based on the soybean phosphatidylcholine. In: Journal of Pharmaceutical and Biomedical Analysis. 2015 ; Vol. 114. pp. 288-291.
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AU - Zabelin, A. V.

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