Application of siRNA in targeting protein expression in kidney disease

Geurt Stokman, Yu Qin, Zsuzsanna Rácz, Peter Hamar, Leo S. Price

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Although it is one of the major targeted organs by systemically administered siRNA, when compared to other tissues the kidney receives only moderate interest regarding therapeutic siRNA delivery. Here we review recent approaches to target renal protein expression under normal and pathological conditions. Experimental evidence to support the clinical relevance of siRNA administration in the treatment of renal disease is discussed. High-throughput screening using recently available genome-wide RNA interference libraries provides a new, powerful tool that can be applied to conventional and 3D in vitro culture models for lead finding or the identification of signal pathway involvement in renal disease.

Original languageEnglish
Pages (from-to)1378-1389
Number of pages12
JournalAdvanced Drug Delivery Reviews
Volume62
Issue number14
DOIs
Publication statusPublished - Nov 30 2010

Keywords

  • High-throughput
  • Injury
  • Renal
  • Screen
  • SiRNA
  • Therapy

ASJC Scopus subject areas

  • Pharmaceutical Science

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