Rekombinált aktivált VII-faktor alkalmazása veleszületett XI-es faktorhiányban szenvedo két nobeteg vérzéses szövodményének kezelésében, megelozésében, ortopéd sebészeti, illetve traumatológiai beavatkozás során. Esetismertetések

Translated title of the contribution: Application of recombinant, activated Factor VII in the treatment and prevention of the bleeding complication of two female patients suffering from congenital XI factor deficiency during orthopedic and traumatology intervention

Bence Moravcsik, L. Nemes, Lajos Zsiros

Research output: Contribution to journalArticle

Abstract

The authors describe the treatment of the bleeding complications in two female patients suffering from a rare, inherited coagulation disorder; Factor XI deficiency after having major orthopaedic and traumatologic operations by activated, recombinant Factor VII (NovoSeven®, Novo Nordisk, Bagsvaerd, Denmark). In the first case a total hip arthroplasty was performed because of severe, left-sided osteoarthritis. Despite of the standard protocol prescribed by the National Haemophilia Centre, severe bleeding complication occurred. The authors describe the pattern of the postoperative bleeding, the difficult decision on reoperation and the experience with activated, recombinant Factor VII, as a rescue treatment. In the second case the patient had a right per trochanter breakage after falling. In her anamnesis it was known that she had severe bleeding complications despite factor substitution. After discussion with the National Haemophilia Centre operation was made by the use of NovoSeven®.

Original languageHungarian
Pages (from-to)1565-1568
Number of pages4
JournalOrvosi Hetilap
Volume149
Issue number33
DOIs
Publication statusPublished - Aug 17 2008

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Factor XI Deficiency
Factor VIIa
Traumatology
Orthopedics
Hemorrhage
Hemophilia A
Inherited Blood Coagulation Disorders
Accidental Falls
Denmark
Therapeutics
Reoperation
Osteoarthritis
Arthroplasty
Femur
Hip

ASJC Scopus subject areas

  • Medicine(all)

Cite this

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title = "Rekombin{\'a}lt aktiv{\'a}lt VII-faktor alkalmaz{\'a}sa velesz{\"u}letett XI-es faktorhi{\'a}nyban szenvedo k{\'e}t nobeteg v{\'e}rz{\'e}ses sz{\"o}vodm{\'e}ny{\'e}nek kezel{\'e}s{\'e}ben, megeloz{\'e}s{\'e}ben, ortop{\'e}d seb{\'e}szeti, illetve traumatol{\'o}giai beavatkoz{\'a}s sor{\'a}n. Esetismertet{\'e}sek",
abstract = "The authors describe the treatment of the bleeding complications in two female patients suffering from a rare, inherited coagulation disorder; Factor XI deficiency after having major orthopaedic and traumatologic operations by activated, recombinant Factor VII (NovoSeven{\circledR}, Novo Nordisk, Bagsvaerd, Denmark). In the first case a total hip arthroplasty was performed because of severe, left-sided osteoarthritis. Despite of the standard protocol prescribed by the National Haemophilia Centre, severe bleeding complication occurred. The authors describe the pattern of the postoperative bleeding, the difficult decision on reoperation and the experience with activated, recombinant Factor VII, as a rescue treatment. In the second case the patient had a right per trochanter breakage after falling. In her anamnesis it was known that she had severe bleeding complications despite factor substitution. After discussion with the National Haemophilia Centre operation was made by the use of NovoSeven{\circledR}.",
keywords = "Activated, Factor XI deficiency, Postoperative bleeding, Recombinant Factor VII, Rosenthal syndrome, Total hip replacement",
author = "Bence Moravcsik and L. Nemes and Lajos Zsiros",
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AU - Nemes, L.

AU - Zsiros, Lajos

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N2 - The authors describe the treatment of the bleeding complications in two female patients suffering from a rare, inherited coagulation disorder; Factor XI deficiency after having major orthopaedic and traumatologic operations by activated, recombinant Factor VII (NovoSeven®, Novo Nordisk, Bagsvaerd, Denmark). In the first case a total hip arthroplasty was performed because of severe, left-sided osteoarthritis. Despite of the standard protocol prescribed by the National Haemophilia Centre, severe bleeding complication occurred. The authors describe the pattern of the postoperative bleeding, the difficult decision on reoperation and the experience with activated, recombinant Factor VII, as a rescue treatment. In the second case the patient had a right per trochanter breakage after falling. In her anamnesis it was known that she had severe bleeding complications despite factor substitution. After discussion with the National Haemophilia Centre operation was made by the use of NovoSeven®.

AB - The authors describe the treatment of the bleeding complications in two female patients suffering from a rare, inherited coagulation disorder; Factor XI deficiency after having major orthopaedic and traumatologic operations by activated, recombinant Factor VII (NovoSeven®, Novo Nordisk, Bagsvaerd, Denmark). In the first case a total hip arthroplasty was performed because of severe, left-sided osteoarthritis. Despite of the standard protocol prescribed by the National Haemophilia Centre, severe bleeding complication occurred. The authors describe the pattern of the postoperative bleeding, the difficult decision on reoperation and the experience with activated, recombinant Factor VII, as a rescue treatment. In the second case the patient had a right per trochanter breakage after falling. In her anamnesis it was known that she had severe bleeding complications despite factor substitution. After discussion with the National Haemophilia Centre operation was made by the use of NovoSeven®.

KW - Activated

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KW - Recombinant Factor VII

KW - Rosenthal syndrome

KW - Total hip replacement

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