Applicazione di biomarkers molecolari epidemiologici mediante il monitoraggiodegli effetti del trattamento nel cancro colorettale durante uno studio di follow

Translated title of the contribution: Application of molecular epidemiological biomarkers by monitoring the effects of treatment in colorectal cancer during follow-up study

Ágoston Ember, Ferenc Budán, Ghodratollah Nowrasteh, Timea Varjas, Ida Prantner, Gyula Gobel, Örs Péter Horvath, Lászlo Illényi, József Cseh, Pál Perjési, Zsuzsa Orsós, Péter Gergely, Katalin Fehér, István Ember, István Kiss

Research output: Contribution to journalArticle

Abstract

Aim. We tested the applicabilityy of expression ofonco/tumor suppressor genes as biomarkers for monitoring the therapeutical efficacy of colorectal cancer, and compared it with traditional tumor markers (CA19-9 and CEA) and with the total blood antioxidant capacity. Materials and methods. In our follow-up study the expression of oncogenes and tumor suppressorgenes of colorectal cancer patients was examined from peripheral blood. The expression of c-myc, Haras, Bcl-2 oncogene and p53 tumor suppressor gene was measured and compared tothe level of classical tumor markers, such as CA19-9 and CEA, and the antioxidant capacity in the blood was measured as well. The tests were performed on the day of surgery, on the seventh post operative day, and after 3, 6, 12 months. Twenty patients, with locally advanced disease took part in the study. Neoadjuvant chemoradiotherapy was given to the patients according to the onco-surgical guidelines. Results. The level of c-myc expression was continuously decreasing after surgery. The other oncogenes and the p53 tumor suppressor gene showed different patterns, but all the examined genes showed significantly lower expression 12 months after surgery. The CA19-9 level showed a decrease during the follow-up, while the CEA concentration was increasing, but both markers presentedan elevated level at the 12th month of the study. The changes in the blood antioxidant capacity showed variable values, no correlation with other markers was observed. Conclusions. The expression of the studied genes was found to be in a good correlation with the efficacy of the surgery, enabling monitoring the status of CRC patients better than with traditional tumor markers.

Original languageItalian
Pages (from-to)99-104
Number of pages6
JournalEuropean Journal of Oncology
Volume16
Issue number2
Publication statusPublished - Jun 1 2011

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Keywords

  • Chemotherapy
  • Colorectal cancer
  • Gene expression
  • Molecular epidemiological biomarkers

ASJC Scopus subject areas

  • Oncology

Cite this

Ember, Á., Budán, F., Nowrasteh, G., Varjas, T., Prantner, I., Gobel, G., Horvath, Ö. P., Illényi, L., Cseh, J., Perjési, P., Orsós, Z., Gergely, P., Fehér, K., Ember, I., & Kiss, I. (2011). Applicazione di biomarkers molecolari epidemiologici mediante il monitoraggiodegli effetti del trattamento nel cancro colorettale durante uno studio di follow. European Journal of Oncology, 16(2), 99-104.