Egy új típusú polimer, az in situ gélesedo tiolált poliaszparaginsav alkalmazása szemészeti gyógyszerhordozóként

Translated title of the contribution: Application of in situ gelling mucoadhesive thiolated polyiaspartic acid) in ophthalmic drug delivery

Horvát Gabriella, Budai Szucs Mária, Berkó Szilvia, P. Szabó-Révész, Gyarmati Benjámin, Szilágyi Barnabás Áron, A. Szilágyi, Csányi Erzsébet

Research output: Contribution to journalArticle

Abstract

The bioavailability of drugs used on mucosal surfaces can be increased by the use of mucoadhesive polymers. A new type of mucoadhesive polymers is the group of thiolated polymers with thiol group containing side chains. These polymers are able to form co-valent bonds (disulphide linkages) with the mucin glycoproteins. For the formulation of an ocular drug delivery system (DDS) thiolated polyiaspartic acid) polymer (ThioPASP) was used. Our aim was to determine their biocompatibility, mucoadhesion and drug release property. According to the results it can be established that the thiolated polyiaspartic acid) polymers can be a potential vehicle of an ocular drug delivery system due to their biocompatibility, good mucoadhesive property and drug release profile. Thanks to their properties controlled drug delivery can be achieved and bioavailability of the ophthalmic formulation can be increased, while the usage frequency can be decreased.

Translated title of the contributionApplication of in situ gelling mucoadhesive thiolated polyiaspartic acid) in ophthalmic drug delivery
Original languageHungarian
Pages (from-to)115-122
Number of pages8
JournalActa Pharmaceutica Hungarica
Volume85
Issue number4
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Pharmaceutical Science

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