Application of differential scanning calorimetry for the diagnosis of musculoskeletal diseases

N. Wiegand, L. G. Nöt, Z. Kiss, D. Lőrinczy

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Background: Despite of the improved biochemical analyzes and imaging technology, diagnosis of different types of musculoskeletal diseases is still challenging. New methods are needed to improve the diagnostic procedures and help to select the most sufficient treatment. Aims: The purpose of our current review was to demonstrate the usefulness of differential scanning calorimetry in the intraoperative diagnosis of musculoskeletal diseases. Materials and methods: Different types of ligaments, connective tissues, joint capsules, arthritic or septic hyaline cartilage were collected intra operatively from pathologic, or healthy human origin. The thermal denaturation of the samples was monitored by a SETARAM Micro DSC-II calorimeter. Results: Here we demonstrated a significant difference in the pattern of the thermal denaturation characteristics of the degenerative or inflamed collagen tissue samples, compared with the healthy human connective tissue. The degenerative samples' thermal enthalpy was significantly decreased, while the melting temperature showed an increase. In case of the inflamed samples, we found a significant increase in the enthalpy and a decrease of melting temperature. Conclusion: These data suggest that DSC analysis could be a clinically relevant, additional method in the intraoperative diagnosis of different types of musculoskeletal diseases.

Original languageEnglish
Title of host publicationMusculoskeletal Diseases: Types, Causes and Treatments
PublisherNova Science Publishers, Inc.
Pages39-55
Number of pages17
ISBN (Print)9781634635721, 9781634635516
Publication statusPublished - Jan 1 2015

Fingerprint

Disease
diagnostic

Keywords

  • cartilage
  • Degenerative
  • DSC (differential scanning calorimetry)
  • inflammatory
  • muscle

ASJC Scopus subject areas

  • Social Sciences(all)

Cite this

Wiegand, N., Nöt, L. G., Kiss, Z., & Lőrinczy, D. (2015). Application of differential scanning calorimetry for the diagnosis of musculoskeletal diseases. In Musculoskeletal Diseases: Types, Causes and Treatments (pp. 39-55). Nova Science Publishers, Inc..

Application of differential scanning calorimetry for the diagnosis of musculoskeletal diseases. / Wiegand, N.; Nöt, L. G.; Kiss, Z.; Lőrinczy, D.

Musculoskeletal Diseases: Types, Causes and Treatments. Nova Science Publishers, Inc., 2015. p. 39-55.

Research output: Chapter in Book/Report/Conference proceedingChapter

Wiegand, N, Nöt, LG, Kiss, Z & Lőrinczy, D 2015, Application of differential scanning calorimetry for the diagnosis of musculoskeletal diseases. in Musculoskeletal Diseases: Types, Causes and Treatments. Nova Science Publishers, Inc., pp. 39-55.
Wiegand N, Nöt LG, Kiss Z, Lőrinczy D. Application of differential scanning calorimetry for the diagnosis of musculoskeletal diseases. In Musculoskeletal Diseases: Types, Causes and Treatments. Nova Science Publishers, Inc. 2015. p. 39-55
Wiegand, N. ; Nöt, L. G. ; Kiss, Z. ; Lőrinczy, D. / Application of differential scanning calorimetry for the diagnosis of musculoskeletal diseases. Musculoskeletal Diseases: Types, Causes and Treatments. Nova Science Publishers, Inc., 2015. pp. 39-55
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