Application of a selective HSQC experiment to measure interglycosidic heteronuclear long-range coupling constants in cyclodextrins

Peter Forgo, Valerian T. D'Souza

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A selective one-dimensional HSQC experiment was used to obtain heteronuclear long-range coupling constants for native and chemically modified cyclodextrins (3,6-anhydro-β-cyclodextrin) and a non-covalent complex of α-cyclodextrin with p-nitrophenol. Selective excitation was performed on C-4 in the α-glucose units using DANTE hard pulse trains. The measured heteronuclear long-range coupling constants have similar values for all natural cyclodextrins. The high value of these coupling constants indicates that the low dihedral angle between H-1 and C-4 found in the solid state is retained in solution. Chemical modification or complex formation, however, decreases the coupling constant by increasing the dihedral angle between these nuclei.

Original languageEnglish
Pages (from-to)48-52
Number of pages5
JournalMagnetic Resonance in Chemistry
Volume37
Issue number1
Publication statusPublished - Jan 1 1999

    Fingerprint

Keywords

  • C NMR
  • Cyclodextrins
  • H NMR
  • HSQC
  • NMR
  • Selective NMR experiments

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)

Cite this