Application of a bipolar nanopore as a sensor: Rectification as an additional device function

Eszter Mádai, Mónika Valiskó, D. Boda

Research output: Contribution to journalArticle

Abstract

We model and simulate a nanopore sensor that selectively binds analyte ions. This binding leads to the modulation of the local concentrations of the ions of the background electrolyte (KCl), and, thus, to the modulation of the ionic current flowing through the pore. The nanopore's wall has a bipolar charge pattern with a larger positive buffer region determining the anions as the main charge carriers and a smaller negative binding region containing binding sites. This charge pattern proved to be an appropriate one as shown by a previous comparative study of varying charge patterns (Mádai et al. J. Mol. Liq., 2019, 283, 391-398.). Binding of the positive analyte ions attracts more anions in the pore thus increasing the current. The asymmetric nature of the pore results in an additional device function, rectification. Our model, therefore, is a dual response device. Using a reduced model of the nanopore studied by a hybrid computer simulation method (Local Equilibrium Monte Carlo coupled with the Nernst-Planck equation) we show that we can create a sensor whose underlying mechanisms are based on the changes in the local electric field as a response to changing thermodynamic conditions. The change in the electric field results in changes in the local ionic concentrations (depletion zones), and, thus, changes in ionic currents.

Original languageEnglish
Pages (from-to)19772-19784
Number of pages13
JournalPhysical Chemistry Chemical Physics
Volume21
Issue number36
DOIs
Publication statusPublished - Jan 1 2019

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Nanopores
rectification
porosity
Anions
sensors
Sensors
hybrid computers
Electric fields
Modulation
Ions
Hybrid computers
anions
modulation
electric fields
Charge carriers
positive ions
Electrolytes
charge carriers
Buffers
ions

ASJC Scopus subject areas

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Cite this

Application of a bipolar nanopore as a sensor : Rectification as an additional device function. / Mádai, Eszter; Valiskó, Mónika; Boda, D.

In: Physical Chemistry Chemical Physics, Vol. 21, No. 36, 01.01.2019, p. 19772-19784.

Research output: Contribution to journalArticle

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