Applicability of sucrose laurate as surfactant in solid dispersions prepared by melt technology

Angéla Szuts, Péter Láng, Rita Ambrus, Lóránd Kiss, Mária A. Deli, Piroska Szabó-Révész

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

This study focused on an investigation of the applicability of sucrose laurate as surfactant in solid dispersions. Although this surfactant has a US Drug Master File, it has not been used so far in internal pharmaceutical products. High drug-loaded solid dispersion systems consisting of gemfibrozil as a model drug and PEG 6000 as a carrier, with or without sucrose laurate (D1216), were prepared by the melting method. Cytotoxicity studies on Caco-2 monolayer cells were also performed, in order to gain information on the applicability of D1216 in oral formulations. The results showed that the presence of the surface-active agent did not affect the solid-state characteristics of the model drug significantly. A markedly improved dissolution of gemfibrozil from the ternary solid dispersion systems was observed as compared with the binary solid dispersion systems. The optimum concentration range of the D1216 in the formulations was determined to be 5-10%. The effective final concentrations of D1216 in the dissolution experiments proved to be non-toxic towards CaCo-2 cells. The results suggest the potential use of D1216 in innovative internal pharmaceutical formulations.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume410
Issue number1-2
DOIs
Publication statusPublished - May 30 2011

Keywords

  • Caco-2 cells
  • Cytotoxicity
  • Gemfibrozil
  • Melt technology
  • PEG 6000
  • Solid dispersion
  • Sucrose laurate
  • Surfactant

ASJC Scopus subject areas

  • Pharmaceutical Science

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