Applicability of some mass spectrometric criteria for the confirmation of pesticide residues

Eugenia Soboleva, Karam Ahad, A. Ámbrus

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

This study was initiated to demonstrate the impact of tolerance intervals calculated based on experimental data and standard criteria on the capability to detect and identify pesticide residues by GC-MS in plant extract. The tolerance intervals specified by the current guidelines and standards (EU, EPA, ISO, EC) result in a large number of false negative values. The tolerance intervals calculated based on the actually measured ion ratios at 2 different probability levels did not provide a better estimate. Based on experimental findings a 2-phase procedure for confirmation of pesticide residues is recommended. The first screening phase comprises identification of those pesticide residues that are likely to be present avoiding false negatives as far as possible. Relatively large tolerance intervals, ±30% of absolute ion abundances ratios, have to be used at this point. When 2 or 3 selected ion ratios are within the established tolerance intervals the residue is confirmed. When the ions detected still indicate the possible presence of a residue the result may be reported as tentatively identified. However, when the result would lead to regulatory action, second confirmatory phase has to be undertaken. This can be achieved with the same GC-MS equipment, by injecting matrix-matched standards of the suspected analyte, in order to compensate for matrix influence on ion ratios. Alternatively, methods using different physico-chemical properties of the compound have to be used. The choice of the technique depends on their availability, time and cost.

Original languageEnglish
Pages (from-to)1123-1129
Number of pages7
JournalThe Analyst
Volume129
Issue number11
DOIs
Publication statusPublished - Nov 2004

Fingerprint

Pesticide Residues
pesticide residue
Pesticides
tolerance
Ions
ion
Plant extracts
plant extract
matrix
Plant Extracts
Chemical properties
chemical property
Screening
Availability
Guidelines
Costs and Cost Analysis
Equipment and Supplies
cost
Costs

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Applicability of some mass spectrometric criteria for the confirmation of pesticide residues. / Soboleva, Eugenia; Ahad, Karam; Ámbrus, A.

In: The Analyst, Vol. 129, No. 11, 11.2004, p. 1123-1129.

Research output: Contribution to journalArticle

Soboleva, Eugenia ; Ahad, Karam ; Ámbrus, A. / Applicability of some mass spectrometric criteria for the confirmation of pesticide residues. In: The Analyst. 2004 ; Vol. 129, No. 11. pp. 1123-1129.
@article{0bd0e9c3ad7841488028aca3b1388d23,
title = "Applicability of some mass spectrometric criteria for the confirmation of pesticide residues",
abstract = "This study was initiated to demonstrate the impact of tolerance intervals calculated based on experimental data and standard criteria on the capability to detect and identify pesticide residues by GC-MS in plant extract. The tolerance intervals specified by the current guidelines and standards (EU, EPA, ISO, EC) result in a large number of false negative values. The tolerance intervals calculated based on the actually measured ion ratios at 2 different probability levels did not provide a better estimate. Based on experimental findings a 2-phase procedure for confirmation of pesticide residues is recommended. The first screening phase comprises identification of those pesticide residues that are likely to be present avoiding false negatives as far as possible. Relatively large tolerance intervals, ±30{\%} of absolute ion abundances ratios, have to be used at this point. When 2 or 3 selected ion ratios are within the established tolerance intervals the residue is confirmed. When the ions detected still indicate the possible presence of a residue the result may be reported as tentatively identified. However, when the result would lead to regulatory action, second confirmatory phase has to be undertaken. This can be achieved with the same GC-MS equipment, by injecting matrix-matched standards of the suspected analyte, in order to compensate for matrix influence on ion ratios. Alternatively, methods using different physico-chemical properties of the compound have to be used. The choice of the technique depends on their availability, time and cost.",
author = "Eugenia Soboleva and Karam Ahad and A. {\'A}mbrus",
year = "2004",
month = "11",
doi = "10.1039/b405024j",
language = "English",
volume = "129",
pages = "1123--1129",
journal = "The Analyst",
issn = "0003-2654",
publisher = "Royal Society of Chemistry",
number = "11",

}

TY - JOUR

T1 - Applicability of some mass spectrometric criteria for the confirmation of pesticide residues

AU - Soboleva, Eugenia

AU - Ahad, Karam

AU - Ámbrus, A.

PY - 2004/11

Y1 - 2004/11

N2 - This study was initiated to demonstrate the impact of tolerance intervals calculated based on experimental data and standard criteria on the capability to detect and identify pesticide residues by GC-MS in plant extract. The tolerance intervals specified by the current guidelines and standards (EU, EPA, ISO, EC) result in a large number of false negative values. The tolerance intervals calculated based on the actually measured ion ratios at 2 different probability levels did not provide a better estimate. Based on experimental findings a 2-phase procedure for confirmation of pesticide residues is recommended. The first screening phase comprises identification of those pesticide residues that are likely to be present avoiding false negatives as far as possible. Relatively large tolerance intervals, ±30% of absolute ion abundances ratios, have to be used at this point. When 2 or 3 selected ion ratios are within the established tolerance intervals the residue is confirmed. When the ions detected still indicate the possible presence of a residue the result may be reported as tentatively identified. However, when the result would lead to regulatory action, second confirmatory phase has to be undertaken. This can be achieved with the same GC-MS equipment, by injecting matrix-matched standards of the suspected analyte, in order to compensate for matrix influence on ion ratios. Alternatively, methods using different physico-chemical properties of the compound have to be used. The choice of the technique depends on their availability, time and cost.

AB - This study was initiated to demonstrate the impact of tolerance intervals calculated based on experimental data and standard criteria on the capability to detect and identify pesticide residues by GC-MS in plant extract. The tolerance intervals specified by the current guidelines and standards (EU, EPA, ISO, EC) result in a large number of false negative values. The tolerance intervals calculated based on the actually measured ion ratios at 2 different probability levels did not provide a better estimate. Based on experimental findings a 2-phase procedure for confirmation of pesticide residues is recommended. The first screening phase comprises identification of those pesticide residues that are likely to be present avoiding false negatives as far as possible. Relatively large tolerance intervals, ±30% of absolute ion abundances ratios, have to be used at this point. When 2 or 3 selected ion ratios are within the established tolerance intervals the residue is confirmed. When the ions detected still indicate the possible presence of a residue the result may be reported as tentatively identified. However, when the result would lead to regulatory action, second confirmatory phase has to be undertaken. This can be achieved with the same GC-MS equipment, by injecting matrix-matched standards of the suspected analyte, in order to compensate for matrix influence on ion ratios. Alternatively, methods using different physico-chemical properties of the compound have to be used. The choice of the technique depends on their availability, time and cost.

UR - http://www.scopus.com/inward/record.url?scp=8844285219&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8844285219&partnerID=8YFLogxK

U2 - 10.1039/b405024j

DO - 10.1039/b405024j

M3 - Article

C2 - 15508043

AN - SCOPUS:8844285219

VL - 129

SP - 1123

EP - 1129

JO - The Analyst

JF - The Analyst

SN - 0003-2654

IS - 11

ER -