Appearance of immunoglobulin G and complement factor C3 in the striatum after transient focal ischemia in the rat

Andras Czurko, Hitoo Nishino

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The pathophysiological feature of brain ischemia-infarct was investigated using immunohistochemistry and Gallyas' silver staining after transient ischemia of the middle cerebral artery (MCA) in the rat. A very strong IgG infiltration with clear-cut borders was detected at one to 3 days in ischemic core areas (lateral striatum and adjacent cortex) that fell into porencephaly later. Complement factor C3 (C3) immunoreactivity (IR) appeared similarly while albumin IR more diffusely. Microglial activation could be observed at 1 day while rounded leukocyte-like elements at 3 days after reperfusion. Data suggest that the early appearance of the IgG/C3 IR bears particular importance after transient MCA ischemia as it could predict the ensuing porencephaly in the chronic stage.

Original languageEnglish
Pages (from-to)51-54
Number of pages4
JournalNeuroscience Letters
Volume166
Issue number1
DOIs
Publication statusPublished - Jan 17 1994

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Keywords

  • Albumin
  • Blood-brain barrier
  • C3
  • IgG
  • Inflammation
  • Ischemia
  • Microglia
  • Middle cerebral artery
  • Rat
  • Serum-protein

ASJC Scopus subject areas

  • Neuroscience(all)

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