Apoptotic and mitotic activity in squamous cell carcinoma cells after combined modality treatment with γ-irradiation and dibromodulcitol

H. Kraxner, L. Tamás, G. Sáfrány, O. Ribári, I. Oláh, E. Hidvégi, G. Répássy, B. Szende

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A-431 squamous cell carcinoma cells were treated in vitro with either 4 Gy radiatio of 15 (or 45) μg/ml dibromodulcitol (DBD), as well as with combined 4 Gy irradiation and DBD, with the latter as either a pretreatment or post-treatment. DBD alone or in combination with radiation had a greater effect on cell proliferation than the effect of radiation alone. The difference is due to a higher level of apoptosis induced by DBD, especially in conjunction with radiation. Such a combination may therefore be useful in the treatment of squamous cell carcinoma, which in general responds poorly to radiation therapy.

Original languageEnglish
Pages (from-to)599-606
Number of pages8
JournalCell Biology International
Volume25
Issue number7
DOIs
Publication statusPublished - 2001

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Mitolactol
Squamous Cell Carcinoma
Radiation
Radiation Effects
Therapeutics
Radiotherapy
Cell Proliferation
Apoptosis

Keywords

  • γ-irradiation
  • Apoptosis
  • Carcinoma cells
  • Dibromodulcitol
  • Mitosis

ASJC Scopus subject areas

  • Cell Biology

Cite this

Apoptotic and mitotic activity in squamous cell carcinoma cells after combined modality treatment with γ-irradiation and dibromodulcitol. / Kraxner, H.; Tamás, L.; Sáfrány, G.; Ribári, O.; Oláh, I.; Hidvégi, E.; Répássy, G.; Szende, B.

In: Cell Biology International, Vol. 25, No. 7, 2001, p. 599-606.

Research output: Contribution to journalArticle

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AU - Ribári, O.

AU - Oláh, I.

AU - Hidvégi, E.

AU - Répássy, G.

AU - Szende, B.

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