Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch.

C. Söti, Amere Subbarao Sreedhar, P. Csermely

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Chaperone function plays a key role in repairing proteotoxic damage and in the maintenance of cell survival. Here we compare the regulatory role of molecular chaperones (heat shock proteins, stress proteins) in cellular senescence, apoptosis and necrosis. We also review the current data on chaperone level and function in aging cells, and list some possible therapeutic interventions. Finally, we postulate a hypothesis, that increasing chaperone occupancy might be an important event which forces cells out of the normal cell cycle towards senescence. In the case of severe stress, this may lead to apoptosis or, following lethal stress, to cell necrosis.

Original languageEnglish
Pages (from-to)39-45
Number of pages7
JournalAging Cell
Volume2
Issue number1
Publication statusPublished - Feb 2003

Fingerprint

Cell Aging
Heat-Shock Proteins
Necrosis
Apoptosis
Molecular Chaperones
Cell Survival
Cell Cycle
Maintenance
Therapeutics

ASJC Scopus subject areas

  • Cell Biology

Cite this

Apoptosis, necrosis and cellular senescence : chaperone occupancy as a potential switch. / Söti, C.; Sreedhar, Amere Subbarao; Csermely, P.

In: Aging Cell, Vol. 2, No. 1, 02.2003, p. 39-45.

Research output: Contribution to journalArticle

@article{f932108d8cf1448a817ef9e3359cf33c,
title = "Apoptosis, necrosis and cellular senescence: chaperone occupancy as a potential switch.",
abstract = "Chaperone function plays a key role in repairing proteotoxic damage and in the maintenance of cell survival. Here we compare the regulatory role of molecular chaperones (heat shock proteins, stress proteins) in cellular senescence, apoptosis and necrosis. We also review the current data on chaperone level and function in aging cells, and list some possible therapeutic interventions. Finally, we postulate a hypothesis, that increasing chaperone occupancy might be an important event which forces cells out of the normal cell cycle towards senescence. In the case of severe stress, this may lead to apoptosis or, following lethal stress, to cell necrosis.",
author = "C. S{\"o}ti and Sreedhar, {Amere Subbarao} and P. Csermely",
year = "2003",
month = "2",
language = "English",
volume = "2",
pages = "39--45",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Apoptosis, necrosis and cellular senescence

T2 - chaperone occupancy as a potential switch.

AU - Söti, C.

AU - Sreedhar, Amere Subbarao

AU - Csermely, P.

PY - 2003/2

Y1 - 2003/2

N2 - Chaperone function plays a key role in repairing proteotoxic damage and in the maintenance of cell survival. Here we compare the regulatory role of molecular chaperones (heat shock proteins, stress proteins) in cellular senescence, apoptosis and necrosis. We also review the current data on chaperone level and function in aging cells, and list some possible therapeutic interventions. Finally, we postulate a hypothesis, that increasing chaperone occupancy might be an important event which forces cells out of the normal cell cycle towards senescence. In the case of severe stress, this may lead to apoptosis or, following lethal stress, to cell necrosis.

AB - Chaperone function plays a key role in repairing proteotoxic damage and in the maintenance of cell survival. Here we compare the regulatory role of molecular chaperones (heat shock proteins, stress proteins) in cellular senescence, apoptosis and necrosis. We also review the current data on chaperone level and function in aging cells, and list some possible therapeutic interventions. Finally, we postulate a hypothesis, that increasing chaperone occupancy might be an important event which forces cells out of the normal cell cycle towards senescence. In the case of severe stress, this may lead to apoptosis or, following lethal stress, to cell necrosis.

UR - http://www.scopus.com/inward/record.url?scp=0042330311&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0042330311&partnerID=8YFLogxK

M3 - Article

C2 - 12882333

AN - SCOPUS:0042330311

VL - 2

SP - 39

EP - 45

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 1

ER -