Apoptosis and p53 expression in human gliomas

László Sipos, Zsolt Szegedi, Imre Fedorcsák, Dénes Áfra, Béla Szende

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Twenty-five human gliomas of different histological grade and type were studied for p53 expression by immunohistochemistry and for apoptosis using ApopTag(TM) method. p53 expression (percentage of positive cells) was highest in anaplastic astrocytomas, followed by low grade astrocytomas and surprisingly in glioblastomas. Granular cytoplasmic p53 positivity appeared in 4/5 low grade oligodendroglioma and in 2/5 low grade mixed oligoastrocytomas. The means of apoptosis index in the different tumor types ranged between 0.8 and 11.5 with the highest values in anaplastic astrocytoma and glioblastomas. Although the number of cases per group were relatively low and the individual vales showed differences it seems that p53 expression is related to the biological aggressiveness of gliomas. It is also suggested that high level of apoptosis in malignant glioma could represent a p53 independent pathway.

Original languageEnglish
Pages (from-to)267-270
Number of pages4
JournalPathology and Oncology Research
Volume4
Issue number4
DOIs
Publication statusPublished - Jan 1 1998

Keywords

  • Apoptosis
  • Gliomas
  • Grade
  • p53 expression

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Apoptosis and p53 expression in human gliomas'. Together they form a unique fingerprint.

  • Cite this