Apoptosis and p53, Bcl-2 and Bax gene expression in parathyroid glands of patients with hyperparathyroidism

B. Szende, Parvaneh Farid, Gyula Végso, F. Perner, L. Kópper

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Altogether 107 patients were operated on at the Department of Transplantation and Surgery of Semmelweis University in the past four years, for clinical symptoms of hyperparathyroidism. Clinical and laboratory data of the patients supported the diagnosis of primary or secondary hyperparathyroidism. Chronically impaired renal function was found in 52 cases. The removed parathyroid glands showed hyperplasia in 54, adenoma in 50 and carcinoma in 3 cases. The majority of parathyroid lesions in primary hyperparathyroidism were adenomas (41 cases) and in secondary hyperparathyroidism were hyperplasias (43 cases). The ratio of oxyphil to chief cells as well as occasional mitotic and apoptotic figures were determined. The oxyphil component was present in both hyperplastic and tumorous lesions. Apoptosis and mitosis were rarely seen in hyperplasias and adenomas (under 2%), whereas in carcinomas 3% of the tumor cells were apoptotic and 4% showed mitosis. Cytoplasmic p53 positivity could be observed in 3 of the adenomas and in 2 of the hyperplasias. The carcinomas, four adenomas and 3 hyperplasias showed nuclear p53 positivity. Bcl-2 and Bax were detected in the cytoplasm of the tumor cells in the majority of adenomas and in the cells of hyperplasias. Oxyphil cells were more frequently positive than chief cells or clear cells. Co-localization of Bcl-2 and Bax was found randomly in all types of lesions. The very low incidence of carcinoma, the low mitotic and apoptotic ratio in adenomas and hyperplasias suggest a potent antiproliferative defense mechanism in the parathyroid cell population. This may also be reflected in the cytoplasmic colocalization of various gene products which regulate cell death and cell proliferation. No significant differences in the p53, Bcl-2 and Bax spectrum were found between the primary and secondary (i.e. renal failure) parathyroid alterations.

Original languageEnglish
Pages (from-to)98-103
Number of pages6
JournalPathology and Oncology Research
Volume10
Issue number2
Publication statusPublished - 2004

Fingerprint

bcl-2 Genes
Parathyroid Glands
Hyperparathyroidism
Adenoma
Hyperplasia
Apoptosis
Gene Expression
Carcinoma
Secondary Hyperparathyroidism
Primary Hyperparathyroidism
Mitosis
Oxyphil Cells
Renal Insufficiency
Neoplasms
Cytoplasm
Cell Death
Transplantation
Cell Proliferation
Kidney
Incidence

Keywords

  • Adenoma
  • Apoptosis
  • Bax
  • Bcl-2
  • Carcinoma
  • Hyperplasia
  • Mitosis
  • p53
  • Parathyroid

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Apoptosis and p53, Bcl-2 and Bax gene expression in parathyroid glands of patients with hyperparathyroidism. / Szende, B.; Farid, Parvaneh; Végso, Gyula; Perner, F.; Kópper, L.

In: Pathology and Oncology Research, Vol. 10, No. 2, 2004, p. 98-103.

Research output: Contribution to journalArticle

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