Le génotype epsilon 4 de l’apolipoprotéine est associé à une moindre amélioration de la fonction cognitive cinq ans après chirurgie cardiaque: une étude rétrospective de cohorte

Translated title of the contribution: Apolipoprotein epsilon 4 genotype is associated with less improvement in cognitive function five years after cardiac surgery: a retrospective cohort study

Karsten Bartels, Yi Ju Li, Yen Wei Li, William D. White, Daniel T. Laskowitz, M. Kertai, Mark Stafford-Smith, Mihai V. Podgoreanu, Mark F. Newman, Joseph P. Mathew

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Purpose: Cognitive performance after cardiac surgery can be impaired, and genetic risk factors have previously been suggested. When compared with other isoforms of the gene, the apolipoprotein epsilon 4 (APOE4) allele is associated with worse outcomes in many neurologic disorders. We hypothesized that the APOE4 allele is associated with less favourable cognitive function five years after surgery. Methods: Caucasian patients enrolled in previously reported prospective cognitive trials in both cardiac and non-cardiac surgery participated in this retrospective cohort study. Neuropsychological function was assessed at baseline and five years postoperatively. The relationship between change in cognitive index score and APOE was evaluated using multivariable linear regression. An additive genetic model toward the epsilon 4 allele was applied with adjustment for baseline cognition, years of education, age, presence of diabetes in both cohorts, and presence of coronary artery disease in the non-cardiac surgery cohort. Results: A total of 357 patients were included in this study. In the cardiac surgery group (n = 233), baseline cognitive index (P 

Original languageFrench
Pages (from-to)618-626
Number of pages9
JournalCanadian Journal of Anaesthesia
Volume62
Issue number6
DOIs
Publication statusPublished - Jun 1 2015

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Apolipoproteins
Cognition
Thoracic Surgery
Cohort Studies
Retrospective Studies
Alleles
Genotype
Genetic Models
Nervous System Diseases
Coronary Artery Disease
Linear Models
Protein Isoforms
Education
Genes

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Le génotype epsilon 4 de l’apolipoprotéine est associé à une moindre amélioration de la fonction cognitive cinq ans après chirurgie cardiaque : une étude rétrospective de cohorte. / Bartels, Karsten; Li, Yi Ju; Li, Yen Wei; White, William D.; Laskowitz, Daniel T.; Kertai, M.; Stafford-Smith, Mark; Podgoreanu, Mihai V.; Newman, Mark F.; Mathew, Joseph P.

In: Canadian Journal of Anaesthesia, Vol. 62, No. 6, 01.06.2015, p. 618-626.

Research output: Contribution to journalArticle

Bartels, Karsten ; Li, Yi Ju ; Li, Yen Wei ; White, William D. ; Laskowitz, Daniel T. ; Kertai, M. ; Stafford-Smith, Mark ; Podgoreanu, Mihai V. ; Newman, Mark F. ; Mathew, Joseph P. / Le génotype epsilon 4 de l’apolipoprotéine est associé à une moindre amélioration de la fonction cognitive cinq ans après chirurgie cardiaque : une étude rétrospective de cohorte. In: Canadian Journal of Anaesthesia. 2015 ; Vol. 62, No. 6. pp. 618-626.
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