Apolipoprotein E e4 allele frequency in patients with multiple system atrophy

Nigel J. Cairns, Penny F. Atkinson, T. Kovács, Andrew J. Lees, Susan E. Daniel, Peter L. Lantos

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The glial cytoplasmic inclusion provides a histological hallmark for multiple system atrophy, a group of neurodegenerative disorders including: striatonigral degeneration, olivopontocerebellar atrophy, and Shy-Drager syndrome. Apolipoprotein E (APOE) genotype was determined by the polymerase chain reaction and restriction digestion of DNA extracted from frozen brain tissue from 22 patients (64.9 ± 2.2 years) with clinically and neuropathologically verified multiple system atrophy (MSA). In addition, brain tissue from 36 age- and sex-matched patients who died with Alzheimer's disease (68.8 ± 1.6 years) and 66 neurologically and psychiatrically normal subjects (66.6 ± 1.8 years) was genotyped. The APOE e4 allele frequency in the Alzheimer's disease subjects was significantly increased (0.44, P <0.001), as has been reported previously. The APOE e4 allele frequency of the MSA cases (0.11) was not significantly different from that of the control subjects (0.12). These data indicate that the APOE e4 allele is not a risk factor for multiple system atrophy.

Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalNeuroscience Letters
Volume221
Issue number2-3
DOIs
Publication statusPublished - 1997

Fingerprint

Apolipoprotein E4
Multiple System Atrophy
Apolipoproteins E
Gene Frequency
Striatonigral Degeneration
Alzheimer Disease
Shy-Drager Syndrome
Olivopontocerebellar Atrophies
Inclusion Bodies
Brain
Neuroglia
Neurodegenerative Diseases
Digestion
Alleles
Genotype
Polymerase Chain Reaction
DNA

Keywords

  • Alzheimer's disease
  • apolipoprotein E
  • multiple system atrophy
  • polymerase chain reaction

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Cairns, N. J., Atkinson, P. F., Kovács, T., Lees, A. J., Daniel, S. E., & Lantos, P. L. (1997). Apolipoprotein E e4 allele frequency in patients with multiple system atrophy. Neuroscience Letters, 221(2-3), 161-164. https://doi.org/10.1016/S0304-3940(96)13316-4

Apolipoprotein E e4 allele frequency in patients with multiple system atrophy. / Cairns, Nigel J.; Atkinson, Penny F.; Kovács, T.; Lees, Andrew J.; Daniel, Susan E.; Lantos, Peter L.

In: Neuroscience Letters, Vol. 221, No. 2-3, 1997, p. 161-164.

Research output: Contribution to journalArticle

Cairns, NJ, Atkinson, PF, Kovács, T, Lees, AJ, Daniel, SE & Lantos, PL 1997, 'Apolipoprotein E e4 allele frequency in patients with multiple system atrophy', Neuroscience Letters, vol. 221, no. 2-3, pp. 161-164. https://doi.org/10.1016/S0304-3940(96)13316-4
Cairns, Nigel J. ; Atkinson, Penny F. ; Kovács, T. ; Lees, Andrew J. ; Daniel, Susan E. ; Lantos, Peter L. / Apolipoprotein E e4 allele frequency in patients with multiple system atrophy. In: Neuroscience Letters. 1997 ; Vol. 221, No. 2-3. pp. 161-164.
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