Az apolipoprotein E és a magzati trisomiák kialakulása.

Translated title of the contribution: Apolipoprotein E and fetal trisomies

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Chromosomal abnormalities are the most frequent genetic disorders observed in live births and miscarriages. Trisomies 21, 18, and 13 are the most frequently observed aneuploidy conditions among them. The biologic mechanism of this phenomenon remains unknown. Apolipoprotein E and its alleles have become the focus of the investigations lately. In this review the authors combined the available data from the literature and compared those results with their own observations. Their results based on determination of apo E alleles by PCR-RFLP method from DNA samples combined from trisomic conceptuses and healthy blood donors in the same population. They did not find significant difference in the distribution of apo E alleles, like it was published in several other author's works. The authors discuss the available theories for the development of trisomic conditions and call the attention for the theory of mtDNA mutations as the possible factor.

Original languageHungarian
Pages (from-to)1923-1927
Number of pages5
JournalOrvosi Hetilap
Volume143
Issue number33
Publication statusPublished - Aug 18 2002

Fingerprint

Trisomy
Apolipoproteins E
Alleles
Biological Phenomena
Inborn Genetic Diseases
Live Birth
Aneuploidy
Spontaneous Abortion
Down Syndrome
Blood Donors
Mitochondrial DNA
Chromosome Aberrations
Restriction Fragment Length Polymorphisms
Polymerase Chain Reaction
Mutation
DNA
Population

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Az apolipoprotein E és a magzati trisomiák kialakulása. / Nagy, B.; Papp, Z.

In: Orvosi Hetilap, Vol. 143, No. 33, 18.08.2002, p. 1923-1927.

Research output: Contribution to journalArticle

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