Apolipoprotein E alleles in women with severe pre-eclampsia

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Abstract

This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (ε2, ε3, ε4) was determined by polymerase chain reaction- restriction fragment length polymorphism in three groups of white women: non- pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo ε2 was highest among women with severe pre-eclampsia (16.6%) followed by non- pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo ε2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre- eclampsia.

Original languageEnglish
Pages (from-to)324-325
Number of pages2
JournalJournal of Clinical Pathology
Volume51
Issue number4
DOIs
Publication statusPublished - 1998

Keywords

  • Apolipoprotein E
  • Gene polymorphism
  • Pre-eclampsia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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