Apolipoprotein E alleles in women with severe pre-eclampsia

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (ε2, ε3, ε4) was determined by polymerase chain reaction- restriction fragment length polymorphism in three groups of white women: non- pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo ε2 was highest among women with severe pre-eclampsia (16.6%) followed by non- pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo ε2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre- eclampsia.

Original languageEnglish
Pages (from-to)324-325
Number of pages2
JournalJournal of Clinical Pathology
Volume51
Issue number4
Publication statusPublished - 1998

Fingerprint

Apolipoproteins E
Pre-Eclampsia
Alleles
Pregnant Women
Apolipoprotein E2
Restriction Fragment Length Polymorphisms
Pregnancy
Polymerase Chain Reaction

Keywords

  • Apolipoprotein E
  • Gene polymorphism
  • Pre-eclampsia

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Apolipoprotein E alleles in women with severe pre-eclampsia. / Nagy, B.; Rigó, J.; Fintor, L.; Karádi, I.; Tóth, T.

In: Journal of Clinical Pathology, Vol. 51, No. 4, 1998, p. 324-325.

Research output: Contribution to journalArticle

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