This study investigated the frequency of apolipoprotein E (apoE) alleles among women with severe pre-eclampsia. The presence of the three most common apoE alleles (ε2, ε3, ε4) was determined by polymerase chain reaction- restriction fragment length polymorphism in three groups of white women: non- pregnant healthy (n = 101), pregnant healthy (n = 52), and pregnant with a diagnosis of severe pre-eclampsia (n = 54). The frequency of apo ε2 was highest among women with severe pre-eclampsia (16.6%) followed by non- pregnant women (12.9%), and those experiencing a healthy pregnancy (10.6%). The higher frequency of the apo ε2 allele detected among women with severe pre-eclampsia suggests that apoE may play a role in the development of pre- eclampsia.
- Apolipoprotein E
- Gene polymorphism
ASJC Scopus subject areas
- Pathology and Forensic Medicine