Apolipoprotein A5 IVS3+476A allelic variant associates with increased trigliceride levels and confers risk for development of metabolic syndrome in Hungarians

P. Kisfali, M. Mohás, A. Maász, Ferenc Hadarits, Lajos Markó, Katalin Horvatovich, Tamás Oroszlán, Zoltán Bagosi, Zoltán Bujtor, B. Gasztonyi, I. Wittmann, B. Melegh

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Metabolic syndrome consists of multiple risk factors that are increasing the cardiovascular mortality. The T-1131C variant of the apolipoprotein A5 gene, associated with increased triglycerides, has been found to confer risk for cardiovascular diseases and metabolic syndrome. Because other naturally occurring variants of the gene also correlate with elevated triglycerides, the possible role of 2 common variants, the IVS3+G476A and T1259C, with metabolic syndrome was investigated. Methods and Results: A total of 213 metabolic syndrome patients and 142 healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism. Serum triglycerides were increased in carriers compared with non-carriers in both groups (p

Original languageEnglish
Pages (from-to)40-43
Number of pages4
JournalCirculation Journal
Volume72
Issue number1
DOIs
Publication statusPublished - 2008

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Triglycerides
Restriction Fragment Length Polymorphisms
Genes
Cardiovascular Diseases
Polymerase Chain Reaction
Mortality
Apolipoprotein A-V
Serum

Keywords

  • APOA5
  • IVS3+G476A
  • Metabolic syndrome
  • Single nucleotide polymorphism
  • T1259C

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology

Cite this

Apolipoprotein A5 IVS3+476A allelic variant associates with increased trigliceride levels and confers risk for development of metabolic syndrome in Hungarians. / Kisfali, P.; Mohás, M.; Maász, A.; Hadarits, Ferenc; Markó, Lajos; Horvatovich, Katalin; Oroszlán, Tamás; Bagosi, Zoltán; Bujtor, Zoltán; Gasztonyi, B.; Wittmann, I.; Melegh, B.

In: Circulation Journal, Vol. 72, No. 1, 2008, p. 40-43.

Research output: Contribution to journalArticle

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AU - Kisfali, P.

AU - Mohás, M.

AU - Maász, A.

AU - Hadarits, Ferenc

AU - Markó, Lajos

AU - Horvatovich, Katalin

AU - Oroszlán, Tamás

AU - Bagosi, Zoltán

AU - Bujtor, Zoltán

AU - Gasztonyi, B.

AU - Wittmann, I.

AU - Melegh, B.

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AB - Background: Metabolic syndrome consists of multiple risk factors that are increasing the cardiovascular mortality. The T-1131C variant of the apolipoprotein A5 gene, associated with increased triglycerides, has been found to confer risk for cardiovascular diseases and metabolic syndrome. Because other naturally occurring variants of the gene also correlate with elevated triglycerides, the possible role of 2 common variants, the IVS3+G476A and T1259C, with metabolic syndrome was investigated. Methods and Results: A total of 213 metabolic syndrome patients and 142 healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism. Serum triglycerides were increased in carriers compared with non-carriers in both groups (p

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