Nerisopam, an anxiolytic and antipsychotic homophthalazine (also called 2,3-benzodiazepine) induces rapid, intense expression of Fos-like immunoreactivity (Fos-LI) in the rostral, dorsomedial and lateral parts of the striatum in the rat. Fos-positive cells also occured in the globus pallidus, the olfactory tubercle and in the accumbens nucleus (in the cone and shell portions) but the substantia nigra, the entopenduncular and the subthalamic nuclei were virtually Fos-negative. Five hours after nerisopam application, howewer, cells in the reticular zone of the substantia nigra showed Fos-immunopositivity. After daily application of nerisopam for two weeks, relatively weak Fos-LI was observed in the striatum and the subthalamic nucleus but not in the globus pallidus. Unilateral surgical transsection of the striato-nigral pathway, which depleted tyrosine hydroxylase immunostaining in the ipsilateral striatum, did not influence nerisopam-induced Fos-LI in the striatal neurons, either ipsi- or contralateral to the knife cut. Our results suggest that the striatal neurons are the primary targets of this anxyolitic and atypical antipsychotic drug in the central nervous system.
|Publication status||Published - Dec 1 1997|
ASJC Scopus subject areas
- Molecular Biology