Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment

C. Thang To, G. Bagdy

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

The effect of chronic fluoxetine and ipsapirone treatment on the anxiogenic effect of centrally administered cholecystokinin (CCK) was studied in the social interaction test in male Sprague-Dawley rats. Intracerebroventricular injection of unsulfated CCK-8 significantly decreased total interaction time and locomotor activity and caused some increase in selfgrooming and a reduction in rearing behaviour in a familiar arena in low light conditions. The selective serotonin reuptake inhibitor antidepressant fluoxetine alone (5 mg/kg, i.p.) also had clear acute anxiogenic actions (decrease in total interaction time, locomotor activity, rearing, increase in selfgrooming) after single dosing, but all these effects were omitted after chronic (3 weeks) treatment. In contrast, a single injection of the 5-HT(1A) receptor partial agonist ipsapirone (5 mg/kg, i.p.) alone had only motor effects (decrease in selfgrooming and rearing), and these effects were preserved after chronic treatment. Chronic fluoxetine treatment (5 mg/kg per day, 3 weeks) abolished the effects of CCK-8 (1 nmol/rat, i.c.v.). Chronic treatment with ipsapirone (5 mg/kg per day, 3 weeks) partially attenuated the effects of CCK-8 (1 nmol/rat, i.c.v.). Our studies provide further evidence for a 5-HT/CCK interaction in the regulation of anxiety.

Original languageEnglish
Pages (from-to)279-282
Number of pages4
JournalNeuropharmacology
Volume38
Issue number2
DOIs
Publication statusPublished - Feb 1999

Fingerprint

Fluoxetine
Cholecystokinin
Locomotion
Therapeutics
Injections
Receptor, Serotonin, 5-HT1A
Serotonin Uptake Inhibitors
Interpersonal Relations
Antidepressive Agents
Sprague Dawley Rats
Serotonin
Anxiety
ipsapirone
Light
cholecystokinin 8

Keywords

  • 5-HT(1A) receptor
  • Anxiety
  • Cholecystokinin octapeptide (CCK-8)
  • Serotonin (5-HT)
  • Social interaction test
  • SSRI antidepressant

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Drug Discovery
  • Pharmacology

Cite this

Anxiogenic effect of central CCK administration is attenuated by chronic fluoxetine or ipsapirone treatment. / To, C. Thang; Bagdy, G.

In: Neuropharmacology, Vol. 38, No. 2, 02.1999, p. 279-282.

Research output: Contribution to journalArticle

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