Antiviral effect of acridinones, thioacridinones and thioacridines

Ilona Mucsi, J. Molnár, T. Masaru, P. Brouant, J. Barbe

Research output: Contribution to journalArticle

Abstract

The antiviral effect of different acridinone, thioacridinone and thioacridine derivatives against herpes simplex virus type 2 ( HSV-2 ) was studied in Vero cells. The inhibitory effect of some thioacridine derivatives on the multiplication of HSV-2 was pronounced while two acridinone derivatives had moderate activity or only slightly affected the virus multiplication. The antiviral effect of these derivatives is dependent on the chemical structure and their effectivity can be explained by complex formation with virus DNA, however, the mechanism of antiviral effect remains the subject of further study.

Original languageEnglish
JournalMedical Microbiology Letters
Volume5
Issue numberSUPPL. 1
Publication statusPublished - 1996

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Antiviral Agents
Human Herpesvirus 2
Vero Cells
DNA Viruses
Viruses

ASJC Scopus subject areas

  • Microbiology (medical)

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Antiviral effect of acridinones, thioacridinones and thioacridines. / Mucsi, Ilona; Molnár, J.; Masaru, T.; Brouant, P.; Barbe, J.

In: Medical Microbiology Letters, Vol. 5, No. SUPPL. 1, 1996.

Research output: Contribution to journalArticle

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