Antiulcer effect of the N- and 0-β-D-glucopyranosides of 5- aminosalicylic acid

Ferenc Sztaricskai, Ildikó E. Takács, Ferenc Pusztai, Gábor Szabó, István Csípõ

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Starting from methyl 5-nitrosalicylate (20) the N- and O-β- glucopyranosyl derivatives (24, 28) of 5-aminosalicylic acid were prepared. The LD50 values of these compounds were determined on mice, and the inhibitory effect of 24 (0.83 mmol/kg) and 28 (1.2 mmol/kg) on gastric ulcer on rats, induced by indomethacin was investigated.

Original languageEnglish
Pages (from-to)321-326
Number of pages6
JournalArchiv der Pharmazie
Volume332
Issue number9
DOIs
Publication statusPublished - Sep 1 1999

Keywords

  • 5-Aminosalicylic acid
  • Colitis ulcerosa
  • Crohn disease
  • Mesalazinum
  • O- and N-glucosides

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery

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