Zoledronsav és daganatellenes aktivitás - bovülo evidenciák

Translated title of the contribution: Antitumor activity of zoledronic acid

Research output: Contribution to journalShort survey

Abstract

Bisphosphonates are used for supportive treatment in bone metastases of malignant diseases. Advance in various therapeutic options, molecular targeted therapies of malignant diseases result in longer survival, and may bring a higher number of patients surviving until development of secondary lesions, e.g. bone metastases. This review summarizes the antitumor activity of the amino-bisphosphonate zoledronate, describing results of in vitro and animal model studies. Zoledronic acid treatment in patients with malignant solid tumors causing bone metastases prolongs their survival. According to the emerging, until now not too large amount of data, zoledronic acid may have a clinically significant and important direct antitumor activity which is resulted by many pathomechanical pathways summarized in this report. Randomized clinical trials are needed for evaluating real life antitumor activity of amino-bisphosphonates.

Translated title of the contributionAntitumor activity of zoledronic acid
Original languageHungarian
Pages (from-to)269-271
Number of pages3
JournalMagyar onkologia
Volume53
Issue number3
DOIs
Publication statusPublished - Sep 1 2009

ASJC Scopus subject areas

  • Medicine(all)

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