Antitumor activity of benzo[a]phenothiazines

Noboru Motohashi, Teruo Kurihara, Kazue Satoh, Hiroshi Sakagami, Ilona Mucsi, Rozalia Pusztai, Margit Szabó, Joseph Molnár

Research output: Contribution to journalReview article

27 Citations (Scopus)

Abstract

We have previously reported on the diverse biological activities of benzo[a]phenothiazines, such as the induction of antitumor and antimutagenic activity in vivo, and differentiation and apoptosis in vitro. The relationship of radical generation and π-spin density or dipole moment was investigated, using quantum-chemical calculation with UHF/PM3. These data suggest that the origin of radical generation by active benzo[a]phenothiazines, which affect such biological activities might be N-atom at postion 12.

Original languageEnglish
Pages (from-to)1837-1842
Number of pages6
JournalAnticancer research
Volume19
Issue number3 A
Publication statusPublished - Aug 30 1999

Keywords

  • Apoptosis
  • Benzo[a]phenothiazines
  • Differentiation
  • Dipole moment
  • MDR
  • Radical
  • Tumor antigen
  • π-spin density

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Motohashi, N., Kurihara, T., Satoh, K., Sakagami, H., Mucsi, I., Pusztai, R., Szabó, M., & Molnár, J. (1999). Antitumor activity of benzo[a]phenothiazines. Anticancer research, 19(3 A), 1837-1842.