Abstract
The neuropeptide galanin has been reported to have a wide range of biological actions both in the central nervous system and in the gastrointestinal tract. Recent works led to the discovery of selective galanin receptor antagonists including M15 (galanin1-12-Pro- substanceP5-11-amide), M35 (galanin1-12-Pro-bradykinin2-9-amide) and C7 (galanin1-12-Pro-spantide-amide). These antagonists were shown to competitively inhibit actions of galanin in the central nervous system. The present study was designed to investigate the effect of galanin, M15, M35 and C7 on gastric acid secretion and gastric emptying. Pentagastrin-stimulated gastric acid secretion was inhibited by galanin (0.1-9 nmol·kg-1·h-1, i.v.) in a dose-dependent manner (ID50= 1.8 ± 0.3 nmol·kg-1·h-1). When 9 nmol·kg-1·h-1 galanin infusion was given, inhibition became almost complete. M15, M35 and C7 (1-9 nmol·kg-1·h-1) did not modify responses of the stomach to galanin, but acted as agonists of galanin on acid secretion. Neither galanin nor its putative antagonists affected the emptying of non-caloric liquids from the stomach. In conclusion, galanin may play an antisecretory role in the regulation of gastric acid secretion but not in the control of gastric emptying of liquids in rats. Its antisecretory action on the stomach is mediated by galanin receptors that are distinct from those in the central nervous system. (C) 2000 Elsevier Science Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 37-42 |
| Number of pages | 6 |
| Journal | Journal of Physiology Paris |
| Volume | 94 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - Jan 2000 |
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Keywords
- Acid secretion
- Chimeric analogues
- Galanin
- Gastric emptying
- Receptor
ASJC Scopus subject areas
- Neuroscience(all)
- Physiology (medical)
Cite this
Antisecretory effects of galanin and its putative antagonists M15, M35 and C7 in the rat stomach. / Kisfalvi, István; Burghardt, B.; Bálint, András; Zelles, T.; Vízi, E.; Varga, G.
In: Journal of Physiology Paris, Vol. 94, No. 1, 01.2000, p. 37-42.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Antisecretory effects of galanin and its putative antagonists M15, M35 and C7 in the rat stomach
AU - Kisfalvi, István
AU - Burghardt, B.
AU - Bálint, András
AU - Zelles, T.
AU - Vízi, E.
AU - Varga, G.
PY - 2000/1
Y1 - 2000/1
N2 - The neuropeptide galanin has been reported to have a wide range of biological actions both in the central nervous system and in the gastrointestinal tract. Recent works led to the discovery of selective galanin receptor antagonists including M15 (galanin1-12-Pro- substanceP5-11-amide), M35 (galanin1-12-Pro-bradykinin2-9-amide) and C7 (galanin1-12-Pro-spantide-amide). These antagonists were shown to competitively inhibit actions of galanin in the central nervous system. The present study was designed to investigate the effect of galanin, M15, M35 and C7 on gastric acid secretion and gastric emptying. Pentagastrin-stimulated gastric acid secretion was inhibited by galanin (0.1-9 nmol·kg-1·h-1, i.v.) in a dose-dependent manner (ID50= 1.8 ± 0.3 nmol·kg-1·h-1). When 9 nmol·kg-1·h-1 galanin infusion was given, inhibition became almost complete. M15, M35 and C7 (1-9 nmol·kg-1·h-1) did not modify responses of the stomach to galanin, but acted as agonists of galanin on acid secretion. Neither galanin nor its putative antagonists affected the emptying of non-caloric liquids from the stomach. In conclusion, galanin may play an antisecretory role in the regulation of gastric acid secretion but not in the control of gastric emptying of liquids in rats. Its antisecretory action on the stomach is mediated by galanin receptors that are distinct from those in the central nervous system. (C) 2000 Elsevier Science Ltd.
AB - The neuropeptide galanin has been reported to have a wide range of biological actions both in the central nervous system and in the gastrointestinal tract. Recent works led to the discovery of selective galanin receptor antagonists including M15 (galanin1-12-Pro- substanceP5-11-amide), M35 (galanin1-12-Pro-bradykinin2-9-amide) and C7 (galanin1-12-Pro-spantide-amide). These antagonists were shown to competitively inhibit actions of galanin in the central nervous system. The present study was designed to investigate the effect of galanin, M15, M35 and C7 on gastric acid secretion and gastric emptying. Pentagastrin-stimulated gastric acid secretion was inhibited by galanin (0.1-9 nmol·kg-1·h-1, i.v.) in a dose-dependent manner (ID50= 1.8 ± 0.3 nmol·kg-1·h-1). When 9 nmol·kg-1·h-1 galanin infusion was given, inhibition became almost complete. M15, M35 and C7 (1-9 nmol·kg-1·h-1) did not modify responses of the stomach to galanin, but acted as agonists of galanin on acid secretion. Neither galanin nor its putative antagonists affected the emptying of non-caloric liquids from the stomach. In conclusion, galanin may play an antisecretory role in the regulation of gastric acid secretion but not in the control of gastric emptying of liquids in rats. Its antisecretory action on the stomach is mediated by galanin receptors that are distinct from those in the central nervous system. (C) 2000 Elsevier Science Ltd.
KW - Acid secretion
KW - Chimeric analogues
KW - Galanin
KW - Gastric emptying
KW - Receptor
UR - http://www.scopus.com/inward/record.url?scp=0342859339&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0342859339&partnerID=8YFLogxK
U2 - 10.1016/S0928-4257(99)00105-9
DO - 10.1016/S0928-4257(99)00105-9
M3 - Article
C2 - 10761687
AN - SCOPUS:0342859339
VL - 94
SP - 37
EP - 42
JO - Journal de Physiologie
JF - Journal de Physiologie
SN - 0928-4257
IS - 1
ER -