Antisecretory effects of galanin and its putative antagonists M15, M35 and C7 in the rat stomach

István Kisfalvi, B. Burghardt, András Bálint, T. Zelles, E. Vízi, G. Varga

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

The neuropeptide galanin has been reported to have a wide range of biological actions both in the central nervous system and in the gastrointestinal tract. Recent works led to the discovery of selective galanin receptor antagonists including M15 (galanin1-12-Pro- substanceP5-11-amide), M35 (galanin1-12-Pro-bradykinin2-9-amide) and C7 (galanin1-12-Pro-spantide-amide). These antagonists were shown to competitively inhibit actions of galanin in the central nervous system. The present study was designed to investigate the effect of galanin, M15, M35 and C7 on gastric acid secretion and gastric emptying. Pentagastrin-stimulated gastric acid secretion was inhibited by galanin (0.1-9 nmol·kg-1·h-1, i.v.) in a dose-dependent manner (ID50= 1.8 ± 0.3 nmol·kg-1·h-1). When 9 nmol·kg-1·h-1 galanin infusion was given, inhibition became almost complete. M15, M35 and C7 (1-9 nmol·kg-1·h-1) did not modify responses of the stomach to galanin, but acted as agonists of galanin on acid secretion. Neither galanin nor its putative antagonists affected the emptying of non-caloric liquids from the stomach. In conclusion, galanin may play an antisecretory role in the regulation of gastric acid secretion but not in the control of gastric emptying of liquids in rats. Its antisecretory action on the stomach is mediated by galanin receptors that are distinct from those in the central nervous system. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalJournal of Physiology Paris
Volume94
Issue number1
DOIs
Publication statusPublished - Jan 2000

Fingerprint

Galanin
Stomach
Gastric Acid
Galanin Receptors
Amides
Central Nervous System
Gastric Emptying
galantide
Pentagastrin
Neuropeptides
Gastrointestinal Tract
Acids

Keywords

  • Acid secretion
  • Chimeric analogues
  • Galanin
  • Gastric emptying
  • Receptor

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

Cite this

Antisecretory effects of galanin and its putative antagonists M15, M35 and C7 in the rat stomach. / Kisfalvi, István; Burghardt, B.; Bálint, András; Zelles, T.; Vízi, E.; Varga, G.

In: Journal of Physiology Paris, Vol. 94, No. 1, 01.2000, p. 37-42.

Research output: Contribution to journalArticle

@article{3d6ff0b2c3f94981b275dd40b4ade411,
title = "Antisecretory effects of galanin and its putative antagonists M15, M35 and C7 in the rat stomach",
abstract = "The neuropeptide galanin has been reported to have a wide range of biological actions both in the central nervous system and in the gastrointestinal tract. Recent works led to the discovery of selective galanin receptor antagonists including M15 (galanin1-12-Pro- substanceP5-11-amide), M35 (galanin1-12-Pro-bradykinin2-9-amide) and C7 (galanin1-12-Pro-spantide-amide). These antagonists were shown to competitively inhibit actions of galanin in the central nervous system. The present study was designed to investigate the effect of galanin, M15, M35 and C7 on gastric acid secretion and gastric emptying. Pentagastrin-stimulated gastric acid secretion was inhibited by galanin (0.1-9 nmol·kg-1·h-1, i.v.) in a dose-dependent manner (ID50= 1.8 ± 0.3 nmol·kg-1·h-1). When 9 nmol·kg-1·h-1 galanin infusion was given, inhibition became almost complete. M15, M35 and C7 (1-9 nmol·kg-1·h-1) did not modify responses of the stomach to galanin, but acted as agonists of galanin on acid secretion. Neither galanin nor its putative antagonists affected the emptying of non-caloric liquids from the stomach. In conclusion, galanin may play an antisecretory role in the regulation of gastric acid secretion but not in the control of gastric emptying of liquids in rats. Its antisecretory action on the stomach is mediated by galanin receptors that are distinct from those in the central nervous system. (C) 2000 Elsevier Science Ltd.",
keywords = "Acid secretion, Chimeric analogues, Galanin, Gastric emptying, Receptor",
author = "Istv{\'a}n Kisfalvi and B. Burghardt and Andr{\'a}s B{\'a}lint and T. Zelles and E. V{\'i}zi and G. Varga",
year = "2000",
month = "1",
doi = "10.1016/S0928-4257(99)00105-9",
language = "English",
volume = "94",
pages = "37--42",
journal = "Journal de Physiologie",
issn = "0928-4257",
publisher = "Elsevier Masson SAS",
number = "1",

}

TY - JOUR

T1 - Antisecretory effects of galanin and its putative antagonists M15, M35 and C7 in the rat stomach

AU - Kisfalvi, István

AU - Burghardt, B.

AU - Bálint, András

AU - Zelles, T.

AU - Vízi, E.

AU - Varga, G.

PY - 2000/1

Y1 - 2000/1

N2 - The neuropeptide galanin has been reported to have a wide range of biological actions both in the central nervous system and in the gastrointestinal tract. Recent works led to the discovery of selective galanin receptor antagonists including M15 (galanin1-12-Pro- substanceP5-11-amide), M35 (galanin1-12-Pro-bradykinin2-9-amide) and C7 (galanin1-12-Pro-spantide-amide). These antagonists were shown to competitively inhibit actions of galanin in the central nervous system. The present study was designed to investigate the effect of galanin, M15, M35 and C7 on gastric acid secretion and gastric emptying. Pentagastrin-stimulated gastric acid secretion was inhibited by galanin (0.1-9 nmol·kg-1·h-1, i.v.) in a dose-dependent manner (ID50= 1.8 ± 0.3 nmol·kg-1·h-1). When 9 nmol·kg-1·h-1 galanin infusion was given, inhibition became almost complete. M15, M35 and C7 (1-9 nmol·kg-1·h-1) did not modify responses of the stomach to galanin, but acted as agonists of galanin on acid secretion. Neither galanin nor its putative antagonists affected the emptying of non-caloric liquids from the stomach. In conclusion, galanin may play an antisecretory role in the regulation of gastric acid secretion but not in the control of gastric emptying of liquids in rats. Its antisecretory action on the stomach is mediated by galanin receptors that are distinct from those in the central nervous system. (C) 2000 Elsevier Science Ltd.

AB - The neuropeptide galanin has been reported to have a wide range of biological actions both in the central nervous system and in the gastrointestinal tract. Recent works led to the discovery of selective galanin receptor antagonists including M15 (galanin1-12-Pro- substanceP5-11-amide), M35 (galanin1-12-Pro-bradykinin2-9-amide) and C7 (galanin1-12-Pro-spantide-amide). These antagonists were shown to competitively inhibit actions of galanin in the central nervous system. The present study was designed to investigate the effect of galanin, M15, M35 and C7 on gastric acid secretion and gastric emptying. Pentagastrin-stimulated gastric acid secretion was inhibited by galanin (0.1-9 nmol·kg-1·h-1, i.v.) in a dose-dependent manner (ID50= 1.8 ± 0.3 nmol·kg-1·h-1). When 9 nmol·kg-1·h-1 galanin infusion was given, inhibition became almost complete. M15, M35 and C7 (1-9 nmol·kg-1·h-1) did not modify responses of the stomach to galanin, but acted as agonists of galanin on acid secretion. Neither galanin nor its putative antagonists affected the emptying of non-caloric liquids from the stomach. In conclusion, galanin may play an antisecretory role in the regulation of gastric acid secretion but not in the control of gastric emptying of liquids in rats. Its antisecretory action on the stomach is mediated by galanin receptors that are distinct from those in the central nervous system. (C) 2000 Elsevier Science Ltd.

KW - Acid secretion

KW - Chimeric analogues

KW - Galanin

KW - Gastric emptying

KW - Receptor

UR - http://www.scopus.com/inward/record.url?scp=0342859339&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0342859339&partnerID=8YFLogxK

U2 - 10.1016/S0928-4257(99)00105-9

DO - 10.1016/S0928-4257(99)00105-9

M3 - Article

C2 - 10761687

AN - SCOPUS:0342859339

VL - 94

SP - 37

EP - 42

JO - Journal de Physiologie

JF - Journal de Physiologie

SN - 0928-4257

IS - 1

ER -